prikaz prve stranice dokumenta Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome
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Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome
World Journal of Gastroenterology, 28 (2022), 1; 23-46. https://doi.org/10.3748/wjg.v28.i1.23
Sikirić, Predrag; Škrtić, Anita; Gojković, Slaven; Krezić, Ivan; Žižek, Helena; Lovrić, Eva; Sikirić, Sunčana; Knežević, Mario; Štrbe, Sanja; Milavić, Marija; Kokot, Antonio; Boban Blagaić, Alenka; Seiwerth, Sven

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Sikirić, P., Škrtić, A., Gojković, S., Krezić, I., Žižek, H., Lovrić, E. ... Seiwerth, S. (2022). Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome. World Journal of Gastroenterology, 28. (1), 23-46. doi: 10.3748/wjg.v28.i1.23

Sikirić, Predrag, et al. "Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome." World Journal of Gastroenterology, vol. 28, br. 1, 2022, str. 23-46. https://doi.org/10.3748/wjg.v28.i1.23

Sikirić, Predrag, Anita Škrtić, Slaven Gojković, Ivan Krezić, Helena Žižek, Eva Lovrić, Sunčana Sikirić, et al. "Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome." World Journal of Gastroenterology 28, br. 1 (2022): 23-46. https://doi.org/10.3748/wjg.v28.i1.23

Sikirić, P., et al. (2022) 'Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome', World Journal of Gastroenterology, 28(1), str. 23-46. doi: 10.3748/wjg.v28.i1.23

Sikirić P, Škrtić A, Gojković S, Krezić I, Žižek H, Lovrić E, i sur.. Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome. World Journal of Gastroenterology [Internet]. 07.01.2022. [pristupljeno 22.11.2024.];28(1):23-46. doi: 10.3748/wjg.v28.i1.23

P. Sikirić, et al., "Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome", World Journal of Gastroenterology, vol. 28, br. 1, str. 23-46, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:440084. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:440084
Podaci o radu
Naslov (engleski)Gastric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome
AutorPredrag Sikirić
AutorAnita Škrtić
AutorSlaven Gojković
AutorIvan Krezić
AutorHelena Žižek
AutorEva Lovrić
AutorSunčana Sikirić
AutorMario Knežević
AutorSanja Štrbe
MBZ: 319335
AutorMarija Milavić
AutorAntonio Kokot
AutorAlenka Boban Blagaić
AutorSven Seiwerth
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
The stable gastric pentadecapeptide BPC 157 counteracts various venous occlusion-induced syndromes. Summarized are all these arguments, in the Robert's cytoprotection concept, to substantiate the resolution of different major vessel occlusion disturbances, in particular ischemia-reperfusion injury following the Pringle maneuver and Budd-Chiari syndrome, which was obtained by BPC 157 therapy. Conceptually, there is a new point, namely, endothelium maintenance to epithelium maintenance (the recruitment of collateral blood vessels to compensate for vessel occlusion and reestablish blood flow or bypass the occluded or ruptured vessel). In this paper, we summarize the evidence of the native cytoprotective gastric pentadecapeptide BPC 157, which is stable in the human gastric juice, is a membrane stabilizer and counteracts gut-leaky syndrome. As a particular target, it is distinctive from the standard peptide growth factors, involving particular molecular pathways and controlling VEGF and NO pathways. In the early 1990s, BPC 157 appeared as a late outbreak of the Robert's and Szabo's cytoprotection-organoprotection concept, like the previous theoretical/practical breakthrough in the 1980s and the brain-gut axis and gut-brain axis. As the time went on, with its reported effects, it is likely most useful theory practical implementation and justification. Meantime, several reviews suggest that BPC 157, which does not have a lethal dose, has profound cytoprotective activity, used to be demonstrated in ulcerative colitis and multiple sclerosis trials. Likely, it may bring the theory to practical application, starting with the initial argument, no degradation in human gastric juice for more than 24 h, and thereby, the therapeutic effectiveness (including via a therapeutic per-oral regimen) and pleiotropic beneficial effects.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeStručni rad - Uvodnik
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Gastroenterology
Brojčani podacivol. 28, br. 1, str. 23-46
p-ISSN1007-9327
DOIhttps://doi.org/10.3748/wjg.v28.i1.23
URN:NBNurn:nbn:hr:105:440084
Datum objave publikacije2022-01-07
URL dokumentahttps://www.wjgnet.com/1007-9327/full/v28/i1/23.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2022-11-14 09:17:53