Depression and anxiety are the most common mental health illnesses worldwide. According to large population-based surveys, up to 33.7% of the population are affected by an anxiety disorder during their lifetime (1) and, according to the WHO about 6% of the population is affected by depression worldwide. Medications have a key role in controlling and reducing the symptoms of these mental conditions together with psychotherapy technique. Unfortunately, the side effects of such medication tend to appear before the desirable outcome of their usage start to effect the patients. This phenomena cause non-compliance in the patients’ population. Since many of these patients have comorbidities and therefore are more likely to be treated with more than one medication, it is more likely for them to experience those undesirable side effects. It is of crucial importance that healthcare providers will be aware of the side effects profile of these medication in order to change the prescription to a lower dose or an alternative medication. The benefits of a well-treated patient are not only to the individual but to the family, community and the economy as the outpatient setting are allowing the patient to maintain normal lifestyle and the therapy is many folds cheaper than hospitalization due to these conditions or their complications.