Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) and part of the group of demyelinating diseases of the CNS. The main characteristics of MS are neurodegeneration, inflammation, and demyelination. There are three phenotypes of MS, each phenotype represents a stage in the disease progression, and each phenotype has its characteristics. However, those phenotypes usually overlap, and only in the retrospective patient history is it possible to know when there was a change in the phenotype. Therapy strategies for MS are to decrease the disease's biological activity, treat an acute attack of MS, and provide symptom relief through disease-modifying therapies and immunomodulation. The analgesic effect of cannabis and its anti-inflammatory effect on the immune system and cannabis-based therapy are being investigated, and there is much interest in using cannabis as immunomodulation. Several studies were done, and some are still ongoing in order to examine the use of Cannabis in MS-related spasticity and MS-related pain. This thesis will provide an overview of current knowledge about cannabis treatment in MS.