Graves' disease (GB) is an autoimmune thyroid disease and the most common cause of hyperthyroidism. It affects the middle-aged population and is more common in women. It presents with symptoms and signs such as hyperactivity, irritability, sweating, fatigue, weight loss with increased appetite, tachycardia, atrial fibrillation, tremors and many others. It is also characterized by the goiter, thyroid orbitopathy and dermatopathy. According to European guidelines, the 1st line of treatment is thyrostatic drugs, but if remission cannot be achieved with them, other treatment modalities such as radioiodine ablation and thyroidectomy should be considered. The outcome of Graves' disease is difficult to predict. Higher serum thyroid hormone and TSH-R-Ab levels, goiter size, younger age, smoking, and orbitopathy are associated with a higher risk of relapse. The aim of this research is to retrospectively analyze the clinical characteristics and outcome of treatment of patients with Graves' disease. 93 patients with hyperthyroidism participated in the study, of which 63 were patients with Graves' disease who were treated at the Zagreb Clinical Hospital Center at the Department of Endocrinology. The results showed that the most common causes of hyperthyroidism are Graves' disease (68.48%) and toxic multinodular goiter (19.57%). All patients were initially treated with thyrostatic drugs. According to our results, 63.46% of patients were in remission in 5 years after therapy with thyrostatic drugs. The most common form of additional treatment is radioiodine ablation 15.38%, while a total of 11.54% of patients were treated with total thyroidectomy. Descriptive analysis of the data did not reveal a statistically significant difference between the achievement of remission with thyrostatic drugs and the difference between the gender and age of the patients. According to our results, the average values of T4 hormone are higher in the groups that did not achieve remission with the help of thyroid drugs.