BACKGROUND: Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disease characterised by a progressive rise in lymphocytes of monoclonal origin in peripheral blood, bone marrow, lymph nodes and spleen. For years, chemoimmunotherapy has been gold standard treatment for treatment of this disease. Several large randomised clinical studies have proven the efficiency of maintenance therapy with Rituximab in treatment of follicular lymphomas. Such studies have not been carried out for treatment of CLL, but there have been a couple of research projects with lesser degrees of reliability that indicate benefits of the approach. In accordance with these findings, haematologists from Clinical Hospital Centre Zagreb have started carrying out maintenance therapy on patients with CLL that have had a good response on chemoimmunotherapy. ----- METHODS: This is a retrospective study that analyses outcomes of treatment for patients that have received maintenance therapy with Rituximab between 2015 and 2020. Data has been collected from hospital's informatics system or from the hospital archives. It included patient information, past treatment history, current disease staging and current treatment. ----- RESULTS: Analysis has been performed for 89 patients. Median follow up for the entire group was 40.1 months. At the moment of analysis, disease-free survival and overall survival rates were 58% and 74%. Median event-free survival (EFS) was 42,3 months, while median overall survival (OS) was not reached. Outcomes were affected by induction chemoimmunotherapy, response to induction therapy and cytogenetic profile of the disease. Fludarabine, cyclophosphamide and rituximab (FCR) chemoimmunotherapy have achieved the best results. Median EFS was 57,7 months while median survival was not reached. Side effects were well tolerated. Maintenance therapy resulted with 34% longer EFS for patients treated with later lines of treatment. ----- CONCLUSION: Our research suggests that there are benefits of maintenance therapy. Outcomes are similar to those achieved in other studies.