Malaria is one of the most important infectious parasitic disease in many tropical and subtropical regions in the world caused by blood-borne Plasmodium species parasites. It is estimated that nearly 40% of the world’s population is at risk for acquiring malaria and according to World Health Organisation, there were an estimated 241 million clinical cases of malaria in 2020 globally as well as 627 thousand deaths. Malaria is the most common cause of fever in endemic areas. It can be categorized as uncomplicated or severe, complicated malaria. Patients with uncomplicated malaria disease usually present with weakness, headache, muscle and joint pain, paroxysms of chills, rigor, fever which usually peaks at around 40°C, sweating, fatigue and sleepiness. When the treatment is not effective, or does not start on time, severe malaria can develop with multiple organ dysfunction syndrome. It is presented with cerebral malaria, acute kidney injury, acute respiratory distress syndrome, hypoglycaemia, acidosis and severe anaemia. Light microscopy of Giemsa-stained thick and thin blood smears is the accepted standard for malaria diagnosis. In situations in which expert microscopic examination is delayed or difficult to obtain, Rapid Diagnostic Tests are performed which are based on capturing of parasite antigen from peripheral blood. There are also molecular methods like PCR, biochemical methods, immunoassays, flow cytometry and different approaches to microscopy. Malaria is treated with antimalarial chemotherapeutics. Most commonly used are chloroquine, atovaquone-proguanil, artemether-lumefantrine, mefloquine, primaquine, doxycycline, artemisinin-based combination therapy etc. Drug selection is based on which plasmodium caused the disease, severity of clinical presentation and a part of the world where the infection occurred. The data about parasite resistance to antimalarials are also very important. The treatment of severe malaria is being implemented in intensive care unit and it requires continuous monitoring. Intravenous artesunate is a drug of choice.