Children with autoimmune rheumatic and autoinflammatory diseases have a higher risk of infections due to their underlying disease and the long-term immunosuppressive treatment. The most common infections of these children are respiratory infections and a more severe clinical picture of influenza, which can all be prevented by vaccination. That is why it is important to protect them from vaccine-preventable diseases and to take care of continuous and timely vaccination of such children. The application of mandatory vaccines is carried out according to the latest vaccination calendar in Croatia. Vaccines can be live attenuated or dead / non-living. Depending on the immunosuppressive therapy and the doses at which the drugs are administered, vaccination is given at different times. Vaccination of immunocompromised children is safe with non-live vaccines, and sometimes with live attenuated ones. According to the new guidelines, vaccination recommendations for children with autoimmune rheumatic and autoinflammatory diseases on immunosuppressive therapy are presented. Optional influenza and COVID-19 vaccines are among the most common preventable respiratory diseases. Vaccination against COVID-19 and influenza is especially important in rheumatological patients because such children are more prone to develop complications. Influenza vaccination is recommended in all children suffering from rheumatic diseases as well as their household and contacts. Vaccination against COVID-19 is recommended for all children over the age of 5 due to serious complications of the disease itself.