Repeated implantation failure is defined as the inability to achieve a clinical pregnancy after at least three attempts of in vitro fertilization, whereby in each cycle one to two high-quality embryos are transferred to the uterus. It is estimated that 15% of IVF procedures will result in repeated implantation failure. This can be caused by various paternal and/or maternal and embryonic factors. In order to find out the exact cause that led to RIF, a detailed diagnostic analysis should be performed. Patientsmust undergo an utrasonic and endoscopic examination when needed, to rule out pathological conditions such as endometriosis, adenomyosis, hydrosalpinx, adhesions, fibroids, polyps and congenital anomalies of the uterus. It is also necessary to perform certain laboratory tests in order to rule out hormonal and metabolic disturbances and thrombophilia as well, the conditions that could interfere with embryo implantation. The sperm analysis with the accent on morfology and kariotype analysis of both partners should be the part of standard evaluation of RIF. The embryonic factors that could have a negative impact on implantation includes quality of the embryo, and the possible problem in the performance of the transfer of the embryo into the uterine cavity. The treatment of RIF should be based on the latest scientific research and in addition to all surgical and medicinal methods of treatment, other treatment methods such as psychotherapy and alteration of unhealthy habits (smoking cigarettes, frequent alcohol consumption).should be considered too.