Nearly 25% of melanoma in the human body occurs on head and neck area, despite the fact that head and neck area makes only 9% of body surface. This primary localization appears to have bigger mortality than the rest of the body. According to the WHO classification, there is nine different kinds of melanoma, based on pathogenetic, epidemiologic, clinical and histopathological factors. It is usually diagnosed clinically. The golden standard of melanoma therapy is surgical wide excision. After excision, tissue is sent to pathohistologic analysis in order to detect residual tumor cells in margins. After the procedure, we are faced with a skin defect which should be somehow managed. Depending on the primary tumor location, different kinds of surgical techniques are availible. Every region has its own special characteristics. Reconstruction possibilities are classified on the reconstructive ladder, from the simplest to the most complicated. The simplest one is primary closure, then secondary intention, skin grafts, local and regional flaps and distal flaps. Here we talk about reconstruction of the lesions on special locations – nose, cheek, lips and chin, forehead and scalp and periocular area. Depending on the primary tumor location, there are different ways of limphatic drainage, and different procedures for removal of affected nodes. Other therapeutic modalities are immunotherapy, chemotherapy, biochemotherapy, radiotherapy and gene therapy.