Since the beginning of the COVID-19 pandemic, healthcare systems worldwide have been facing numerous challenges it brought them. Clinical presentation of this illness varies from mild to critical, but a significant amount of asymptomatic cases has been noted as well. The most common symptoms include fever, myalgia, loss of/change in taste or smell and respiratory symptoms like cough. Chronic comorbidities have been recognized as predictors of adverse clinical outcome of COVID-19, with researches showing that prior to availability of vaccination up to 10-15% of all cases required hospitalization. This study aimed to analyze a potential connection between the clinical and laboratory parameters and the need of prolonged hospitalization (>21 days) of patients with SARS-CoV-2 infection. Another one of our goals was analyzing the connection of prolonged hospitalization to patients' comorbidities, as well as the long-term outcomes after discharging hospitalized patients. We have retrospectively analyzed data from the Registry of hospitalized COVID-19 patients in the Respiratory center KB Dubrava. Out of 5959 patients that were analyzed, 799 (13.4%) of them were treated for more than 21 days. We have determined that there is a series of factors connected to prolonged hospitalization, including the severity of COVID-19 symptoms at the time of patient admission, certain chronic comorbidities those patients had, referral from other hospitals and complications that have arised during their stay at the hospital. The data we have obtained also imply that prolonged hospitalization is a negative indicator of patient outcome following their dishcarge from the hospital.