Encephalitis is an inflammation of the brain parenchyma due to infective, postinfective or autoimmune causes. Most frequently occurs infective encephalitis caused by viral infection, followed by acute disseminated encephalomyelitis (ADEM) and the least common one is autoimmune encephalitis. The main goal of this study is to determine the long-term outcome, according to modified Rankin score (mRS), in patients treated for meningoencephalitic syndrome in 2014 and 2015 in University Hospital for Infectious Diseases „Dr. Fran Mihaljević “, Department for Adult Intensive Care and Neuroinfections, and to compare mRS in each patient in 2017 and 2022. This study includes 90 patients ≥18 years of age, who were discharged from the Hospital with the diagnosis of meningoencephalitic syndrome. Hospital data were collected from discharge letters. Data of long-term outcome were collected in 2017 and 2022 via two telephone interviews with a patient, his/her family member or a person a patient is living with. Based on patients’ symptoms, mRS was determined for each patient individually. Both phone calls showed that most patients had mild to moderate disability (mRS 1, mRS 2 and mRS 3) according to Modified Rankin Score. In 2017 there were 44.3% and in 2022 43.6% of patients with mild to moderate disability. The worst health deterioration, between two phone calls, was observed in patients who had postinfectious encephalitis, while the patients who had encephalitis of unknown etiology had the lightest progression of symptoms. None of the observed patients have developed neurodegenerative disease during the time after hospitalisation. A lot of different factors have an influence on the outcomes of the patients with meningoencephalitic syndrome, of whom the most distinctive are the patient’s age, comorbidities and etiology of the disease. Regarding that, long-term outcomes in these patients are extremely variable and include the whole spectrum of symptoms from mild concentration problems to severe motor and sensor neurologic deficits.