Cardiovascular and cerebrovascular diseases are the leading cause of death in Croatia and the world. One of the most important risk factors for the development of cardiovascular diseases is hyperlipidemia. For this reason, the treatment of hyperlipidemia and the maintenance of cholesterol target levels stand out as one of the most important goals in the prevention and treatment of cardiovascular disease. Despite the wide and long-term use of statins, ezetimibe and other lipid-lowering agents, some patients still do not reach the target cholesterol levels, while others have not so rare side effects of these drugs, especially statins. Therefore those patients cannot continue therapy and optimal treatment. For many years, a new way of treating elevated lipid levels has been sought, and PCSK9 inhibitors have emerged as a new and effective therapeutic approach. The discovery of the PCSK9 molecule in 2003 and the development of effective monoclonal antibodies preceded the approval of two currently available monoclonal antibodies, alirocumab and evolocumab . By binding to the serine protease-PCSK9, monoclonal antibodies prevent PCSK9 from interacting with LDL receptors and consequently no LDL receptor degradation occurs. This mechanism leads to a significant reduction in LDL-C levels. Alirocumab and evolocumab are given as subcutaneous injections once every two weeks or once a month. The most common sites of application are the abdomen, thigh and upper arm. In addition to lowering LDL-C levels, they also lead to a significant reduction in the risk of adverse cardiovascular events. These drugs show good tolerability and the most common side effect is an injection site reaction. PCSK9 inhibitors are now an integral part of guidelines for the treatment of hyperlipidemia.