Abdominal and pelvic tumors often spread to the peritoneum. Until the end of the twentieth century, discovering these kinds of metastases meant exclusively palliative, and usually not effective treatment. Progress in molecular biology and clinical oncology resulted in new possibilities for treating patients with advanced malignancies. First attempts in the treatment of malignancies spread to the peritoneum started in the 1980s when Paul H. Sugarbaker developed and started teaching techniques of peritonectomy and cytoreductive surgery for the macroscopic disease. His guiding thought "It's what the surgeon doesn't see that kills the patient," presents clearly limitations of surgery, regional and systemic chemotherapy, but at the same time points out the potential area for progress by simultaneously using surgical procedures and oncological findings 1. Around 30 to 50% of deaths and bowel obstructions happen due to neoplastic cells in abdomen and pelvis that can not be seen by a surgeon during the procedure.2 In the treatment of microscopic disease François N. Gilly and Dominique Elias stand out in particular by inventing the technique of “open“ and “closed“ hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery 3. The development of this area affected multiple other medical professions – radiology, anesthesiology and resuscitation medicine, clinical pharmacology, psychological medicine etc. Regardless of the enormous amount of new findings in the molecular behavior of the metastases, the development of new techniques and treatment algorithms, and more directed treatment due to better staging of the disease, this area is still a point of interest for research. The invention of new techniques such as intraperitoneal targeted therapy, pressurized intraperitoneal aerosol chemotherapy (PIPAC), and laparoscopic HIPEC represents a tendency of the medical and scientific community for targeting the treatment even more in order to increase overall survival and minimize the invasiveness of surgical and oncologic procedures.