Hearing impairment and specific language disorder are two entities that seriously affect language acquisition ability in children and reduce their communication skills. These children require specific treatment and higher level of care. Their language abilities also strongly influence parent child interactions. The purpose of our study was to evaluate health related quality of life (HRQOL) in parents of hearing impaired children, and parents of children with speech difficulties (specific language disorder). The subjects of our study were 349 parents (182 mothers and 167 fathers) of preschool-age children with receptive expressive language disorder and 131 parents (71 mothers and 60 fathers) of children with severe hearing impairment. A control group was composed of 146 parents (82 mothers and 64 fathers) of healthy children of the same age. HRQOL was assessed using SF-36 questionnaire. In all groups of parents mothers scored poorer results compared to the fathers, but with large differences depending on the impairment of the child. In the control group, the results of mothers were significantly lower in only two (out of eight) health domains, in mothers of speech impaired children in three domains, and in six domains in mothers of hearing impaired children, indicating the biggest difference between them and their spouses. When compared to control group, both mothers and fathers of speech impaired children scored signficantly worse in five health dimensions. Fathers of hearing impaired children scored significantly worse than controls in three health dimensions. The lowest results, indicating the poorest HRQOL scored mothers of hearing impaired children, obtaining significantly lower results than control mothers in all of the health domains except for role emotional. The parents of pre-school speech and hearing imapired children experience poorer health related quality of life than parents of healthy children of the same age. Mothers of hearing impaired children are especially affected, demonstrating negative impact in almost all of the health domains.