Mycophenolate mofetil, mycophenolic acid's prodrug is an imunosuppressive drug, which has become a mandatory part of therapy in posttransplantation patients and in some autoimmune diseases. Area under curve (AUC) of mycophenolic acid is in direct connection with successful therapy outcome and has a noticeable interindividual and intraindividual variability when peroral mycophenolate mofetil is used and thus requires a constant surveillance and titration. Furthermore, in several papers an interaction was described of mycophenolate mofetil and other drugs which influence the digestive system and interaction with food. The European Medicines Agency, EMA, currently requires for assessing bioequivalence of generic products of mycophenolate mofetil only a single bioequivalence study in fasting state, while FDA; requires a study in the fasting state and another one in the fed state. While searching through PubMed Medline 16 papers have been found (concerning physiochemical and biopharmaceutical properties of MMF, absorption of MMF from digestive system in humans and animals, clinical effectiveness of generic products of MMF) of which 14 were available in full text. These papers do not give a final answer to the question, but confirm the doubt that there is a significant possibility that current EMA standards for assessing bioequivalence of generic products of mycophenolate mofetil might not guarantee therapeutic equivalence of generics in the real-life environment.