Introduction: Adolescence is a stage of life with fast and large developmental changes, but little is known how these changes affect the quality of life of deaf adolescents. Hearing impairment is evident in their daily interaction with the environment and the effect on language development, social and emotional development and consequently on the quality of life. Timely detection of hearing impairment and early intervention procedures will consequently affect the quality of life (to) deaf children. The modern approach to the rehabilitation and education of children with disabilities focuses on the remaining abilities and improving the quality of life of the child and his family. Goal: The aim of this study was to determine whether there are differences in self-reported quality of life of adolescents with hearing impairment and adolescents with no hearing impairment. Subjects and Methods: The study included 49 adolescents, of which 22 adolescents have hearing loss and 27 have no hearing impairment. The sample consisted of 28 male participants and 21 female participants aged 15 to 17 years. The study was conducted at the Center for Training and Education "Slava Raškaj" and the Nursing school Mlinarska in Zagreb in academic year 2014/2015. Data for the survey were collected from PedsQL™ - Questionnaire to assess the quality of life of pediatric patients, Version 4.0 for adolescents aged 13 to 18 years. The questionnaire consists of 23 particles which measure the participant's physical, emotional, social and school functioning. Results: Adolescents with hearing impairment assessed quality of life worse than adolescents without hearing impairment. The difference is demonstrated in the self-evaluation of physical, social and school functioning, while not proven in self-emotional functioning. Conclusion: Adolescents with hearing impairment have a lower quality of life compared to their normal hearing peers. The differences are present in the physical, social and school functioning.