To make a programme proposal of health preservation and promotion of employees in General Hospital "Dr. Tomislav Bardek" in Koprivnica following the ergonomic principles: syncronisation of conditions and work methods with employees' potentials. Objective: To examine whether there is connection between conditions, work methods, working environment and appearance of musculo-sceletal difficulties of employees in General Hospital Koprivnica. Methods: Voluntarily and anonymous study in which participated 241 employee: 211 (87,6%) women and 30 (12,4%) men, was conducted by hospital intraweb set questionnaires Questionnaire for assessment of work impact on health and work ability and modified OREBRO questionnaire for examination of musculo-sceletal difficulties. Results: Musculo-sceletal difficulties are present in almost every other employee (109 or 45,2%), more often in women, secundary education, older than 50 years. More than half experience plesure in their job: 135 or 56,0%, when 106 (44,0%) is unsatisfied. Burn out syndrome is experienced by 51 employee (21,2%). Psychophysical strains are present in 45 examined (18,7%). Conclusion: It is necessary to undertake ergonomic measures which have to include not only musculo-sceletal but also psychophysical strains. It is necessary to actively include occupational medicine specialist at workplaces and hospital administration, for measures support as well as purchase of appropriate equipment.