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Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia
International Journal of Molecular Sciences, 23 (2022), 20; 12379. https://doi.org/10.3390/ijms232012379
Barbarić Starčević, Katarina; Lukač, Nina; Jelić, Mislav; Šućur, Alan; Grčević, Danka; Kovačić, Nataša

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Barbarić Starčević, K., Lukač, N., Jelić, M., Šućur, A., Grčević, D. i Kovačić, N. (2022). Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia. International Journal of Molecular Sciences, 23. (20). doi: 10.3390/ijms232012379

Barbarić Starčević, Katarina, et al. "Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia." International Journal of Molecular Sciences, vol. 23, br. 20, 2022. https://doi.org/10.3390/ijms232012379

Barbarić Starčević, Katarina, Nina Lukač, Mislav Jelić, Alan Šućur, Danka Grčević i Nataša Kovačić. "Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia." International Journal of Molecular Sciences 23, br. 20 (2022). https://doi.org/10.3390/ijms232012379

Barbarić Starčević, K., et al. (2022) 'Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia', International Journal of Molecular Sciences, 23(20). doi: 10.3390/ijms232012379

Barbarić Starčević K, Lukač N, Jelić M, Šućur A, Grčević D, Kovačić N. Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia. International Journal of Molecular Sciences [Internet]. 16.10.2022. [pristupljeno 28.12.2024.];23(20). doi: 10.3390/ijms232012379

K. Barbarić Starčević, N. Lukač, M. Jelić, A. Šućur, D. Grčević i N. Kovačić, "Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia", International Journal of Molecular Sciences, vol. 23, br. 20, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:727062. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:727062
Podaci o radu
Naslov (engleski)Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia
AutorKatarina Barbarić Starčević
AutorNina Lukač
AutorMislav Jelić
AutorAlan Šućur
AutorDanka Grčević
AutorNataša Kovačić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ORTOPEDIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ortopedija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Rheumatoid arthritis (RA) is chronic, autoimmune joint inflammation characterized by irreversible joint destruction. Besides increased resorption, destruction is a result of decreased bone formation, due to suppressed differentiation and function of the mesenchymal lineage-derived osteoblasts in inflammatory milieu. In this study, we analyzed the cellular composition of synovial tissue from 11 RA and 10 control patients harvested during planned surgeries in order to characterize resident synovial progenitor populations. Synovial cells were released by collagenase, and labeled for flow cytometry by two antibody panels: 1. CD3-FITC, CD14-PE, 7-AAD, CD11b-PECy7, CD235a-APC, CD19-APCeF780; and 2. 7-AAD, CD105-PECy7, CD45/CD31/CD235a-APC, and CD200-APCeF780. The proportions of lymphocytes (CD3+, CD19+) and myeloid (CD11b+, CD14+) cells were higher in synovial tissue from the patients with RA than in the controls. Among non-hematopoietic (CD45−CD31−CD235a−) cells, there was a decrease in the proportion of CD200+CD105− and increase in the proportion of CD200−CD105+ cells in synovial tissue from the patients with RA in comparison to the control patients. The proportions of both populations were associated with inflammatory activity and could discriminate between the RA and the controls.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 20, 12379
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms232012379
URN:NBNurn:nbn:hr:105:727062
Datum objave publikacije2022-10-16
URL dokumentahttps://www.mdpi.com/1422-0067/23/20/12379
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-08-21 07:35:10