prikaz prve stranice dokumenta Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy
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Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy
European Journal of Clinical Pharmacology, 79 (2023), 8; 1117-1129. https://doi.org/10.1007/s00228-023-03526-z
Božina, Nada; Šušak Sporiš, Ivana; Klarica Domjanović, Iva; Ganoci, Lana; Šimičević, Livija; Lovrić, Mila; Čolak Romić, Zrinka; Petelin Gadže, Željka; Trkulja, Vladimir

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Božina, N., Šušak Sporiš, I., Klarica Domjanović, I., Ganoci, L., Šimičević, L., Lovrić, M. ... Trkulja, V. (2023). Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. European Journal of Clinical Pharmacology, 79. (8), 1117-1129. doi: 10.1007/s00228-023-03526-z

Božina, Nada, et al. "Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy." European Journal of Clinical Pharmacology, vol. 79, br. 8, 2023, str. 1117-1129. https://doi.org/10.1007/s00228-023-03526-z

Božina, Nada, Ivana Šušak Sporiš, Iva Klarica Domjanović, Lana Ganoci, Livija Šimičević, Mila Lovrić, Zrinka Čolak Romić, Željka Petelin Gadže i Vladimir Trkulja. "Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy." European Journal of Clinical Pharmacology 79, br. 8 (2023): 1117-1129. https://doi.org/10.1007/s00228-023-03526-z

Božina, N., et al. (2023) 'Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy', European Journal of Clinical Pharmacology, 79(8), str. 1117-1129. doi: 10.1007/s00228-023-03526-z

Božina N, Šušak Sporiš I, Klarica Domjanović I, Ganoci L, Šimičević L, Lovrić M, i sur.. Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. European Journal of Clinical Pharmacology [Internet]. 08.2023. [pristupljeno 05.11.2024.];79(8):1117-1129. doi: 10.1007/s00228-023-03526-z

N. Božina, et al., "Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy", European Journal of Clinical Pharmacology, vol. 79, br. 8, str. 1117-1129, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:062920. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:062920
Podaci o radu
Naslov (engleski)Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy
AutorNada Božina
AutorIvana Šušak Sporiš
AutorIva Klarica Domjanović
AutorLana Ganoci
AutorLivija Šimičević
AutorMila Lovrić
AutorZrinka Čolak Romić
AutorŽeljka Petelin Gadže
AutorVladimir Trkulja
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Purpose: To estimate whether epilepsy patients with variant UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) alleles differ from their wild-type (wt) peers in exposure to lamotrigine. Methods: Consecutive adults on lamotrigine monotherapy or lamotrigine + valproate co-treatment undergoing routine therapeutic drug monitoring, otherwise generally healthy and free of interacting drugs, were genotyped for UGT2B7 -161C > T and UGT1A4*3 c.142 T > G. Heterozygous, variant homozygous, or combined heterozygous/variant homozygous subjects were compared to their wt controls for dose-adjusted lamotrigine troughs with adjustment for age, sex, body weight, rs7668258/rs2011425, polymorphisms of efflux transporter proteins ABCG2 c.421C > A (rs2231142) and ABCB1 1236C > T (rs1128503), and level of exposure to valproate using covariate entropy balancing. Results: Of the 471 included patients, 328 (69.6%) were on monotherapy and 143 were co-treated with valproate. Dose-adjusted lamotrigine troughs in UGT2B7 -161C > T heterozygous (CT, n = 237) or variant homozygous (TT, n = 115) subjects were closely similar to those in their wt controls (CC, n = 119): geometric means ratios (GMRs) (frequentist and Bayes) 1.00 (95%CI 0.86-1.16) and 1.00 (95%CrI 0.83-1.22) for CT vs. CC; and 0.97 (0.81-1.17) and 0.97 (0.80-1.20) for TT vs. CC subjects. Lamotrigine troughs were also closely similar in UGT1A4*3 c.142 T > G variant carriers (n = 106: 102 TG + 4 GG subjects) and wt controls (TT, n = 365): GMR = 0.95 (0.81-1.12) frequentist, 0.96 (0.80-1.16) Bayes. GMRs for variant carriers vs. wt controls were around unity also at different levels of exposure to valproate. Conclusion: Dose-adjusted lamotrigine troughs in epilepsy patients with variant UGT2B7 -161C > T or UGT1A4*3 c.142 T > G alleles are equivalent to those in their respective wt peers.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEuropean Journal of Clinical Pharmacology
Brojčani podacivol. 79, br. 8, str. 1117-1129
p-ISSN0031-6970
e-ISSN1432-1041
DOIhttps://doi.org/10.1007/s00228-023-03526-z
URN:NBNurn:nbn:hr:105:062920
Datum objave publikacije2023-08
URL dokumentahttps://link.springer.com/10.1007/s00228-023-03526-z
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2024-09-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-10-02 09:16:15