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Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers
Medical Science Monitor, 29 (2023); e940356. https://doi.org/10.12659/MSM.940356
Miletić, Dragana; Kraljević, Marija; Sokolović, Emir; Soče, Majana; Milović-Kovačević, Marijana; Bobić, Simonida; Cerić, Timur; Pleština, Stjepko; Bešlija, Semir; Marijanović, Inga

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Miletić, D., Kraljević, M., Sokolović, E., Soče, M., Milović Kovačević, M., Bobić, S. ... Marijanović, I. (2023). Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers. Medical Science Monitor, 29.. doi: 10.12659/MSM.940356

Miletić, Dragana, et al. "Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers." Medical Science Monitor, vol. 29, 2023. https://doi.org/10.12659/MSM.940356

Miletić, Dragana, Marija Kraljević, Emir Sokolović, Majana Soče, Marijana Milović Kovačević, Simonida Bobić, Timur Cerić, Stjepko Pleština, Semir Bešlija i Inga Marijanović. "Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers." Medical Science Monitor 29 (2023). https://doi.org/10.12659/MSM.940356

Miletić, D., et al. (2023) 'Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers', Medical Science Monitor, 29. doi: 10.12659/MSM.940356

Miletić D, Kraljević M, Sokolović E, Soče M, Milović Kovačević M, Bobić S, i sur.. Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers. Medical Science Monitor [Internet]. 17.05.2023. [pristupljeno 28.12.2024.];29. doi: 10.12659/MSM.940356

D. Miletić, et al., "Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers", Medical Science Monitor, vol. 29, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:134002. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:134002
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Naslov (engleski)Differences in Outcomes Between Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer Patients in Upper Middle-Income versus High-Income Countries: A Retrospective Study from 4 Oncology Centers
AutorDragana Miletić
AutorMarija Kraljević
AutorEmir Sokolović
AutorMajana Soče
AutorMarijana Milović-Kovačević
AutorSimonida Bobić
AutorTimur Cerić
AutorStjepko Pleština
AutorSemir Bešlija
AutorInga Marijanović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KLINIČKU ONKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
BACKGROUND Therapeutic options for human epidermal growth factor 2 (HER2)-positive metastatic breast cancer (mBC) are developing rapidly. This study aimed to determine the differences in the survival outcomes of patients with HER2-positive mBC in relation to access to anti-HER therapy at 3 oncology centers in upper-middle-income countries (UMICs) and 1 oncology center in a high-income country (HIC). MATERIAL AND METHODS We retrospectively identified 42 patients from Croatia (HIC), 71 patients from Serbia (UMIC), and 57 from Bosnia and Herzegovina (UMIC) diagnosed with HER2-positive mBC who were treated between January 2015 and December 2020. The pathohistological features of the tumors were obtained from the pathological findings, which were made according to standard procedures for each center. Patients were treated depending on the availability of therapy, which differed for centers in different countries. We evaluated disease-free survival, progression-free survival, and overall survival (OS) based on the availability of first- and second-line anti-HER2 therapy in UMICs vs HIC. RESULTS OS in first-line therapy was better in patients treated with dual HER2 blockade than in patients treated without dual HER2 blockade, P<0.001. OS in second-line therapy was significantly better in patients treated with trastuzumab emtansine than in patients treated with other reported regimens, P=0.004. CONCLUSIONS Results of our study showed superior survival among patients who were treated with dual first-line HER2 therapy as well as second-line trastuzumab emtansine therapy than in those patients in other centers where these drugs were not available. Raising awareness about this could help improve the situation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical Science Monitor
Brojčani podacivol. 29, e940356
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.940356
URN:NBNurn:nbn:hr:105:134002
Datum objave publikacije2023-05-17
URL dokumentahttps://www.medscimonit.com/abstract/index/idArt/940356
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2023-10-05 08:39:44