Non-alcoholic fatty liver disease is the most common chronic liver disease in the Western world. NAFLD is part of metabolic syndrome, which includes central obesity, elevated blood pressure, abnormal levels of cholesterol and triglycerides, and insulin resistance, including type 2 diabetes. An unhealthy diet and reduced physical activity are the main variable risk factors in the development of components of metabolic syndrome, thus, and non-alcoholic fatty liver disease. NAFLD is diagnosed by a combination of laboratory and imaging tests, and in the case of progression to non-alcoholic steatohepatitis, it is confirmed by liver biopsy. NAFLD is defined by the finding of ≥5% accumulated fat in the liver and by excluding secondary causes, such as alcoholism. According to current guidelines, the treatment of NAFLD involves lifestyle changes, with an emphasis on a healthier diet and increased physical activity, and treatment of associated conditions. So far, no specific pharmacological therapy has been approved for the treatment of NAFLD. Glucagon-like peptide-1 receptor agonists are the incretin mimetics currently used in the treatment of type 2 diabetes and obesity and are currently being considered as a new therapeutic option for NAFLD. By administering them, various positive metabolic effects are achieved, such as reducing insulin resistance; reducing appetite, and prolonging satiety; beneficial effects on lipid metabolism with a consequent reduction in the degree of inflammation and fibrosis in the liver.