Primary malignant bone tumors are rare tumors that account for less than 1% of all malignant tumors. Some of the most common types are multiple myeloma, osteosarcoma, chondrosarcoma, and Ewing sarcoma. Osteosarcoma and Ewing sarcoma can be seen more often in adolescents and young adults, while multiple myeloma and chondrosarcoma are more common in older patients. The etiology of these tumors is unknown; however radiation exposure, chemotherapy and syndromes are considered to be possible ethological factors. Benign bone tumors are, on the other hand, relatively common, and remain asymptomatic until their presence is indicated by an injury. They are more common in young age and the most common types are: osteochondromas, giant cell tumors, osteoblastomas and osteoid osteomas. In this final paper the newest World Health Organization Classification that concerns bone tumors will be presented and a short description of distinct features of individual tumors will be provided to, finally, discuss radiological characteristics and features of bone tumors, as well as the newest therapy methods. Special emphasis is placed on differentiating between benign and malignant bone lesions with the help of specific radiological findings – margins, periosteal reaction, cortical expansion, and expansion into soft tissues. Additionally, the newest staging systems and their incidence regarding age and location will be presented. Next, specific radiological findings of benign and malignant bone tumors as well as pathognomonic findings will be presented. Furthermore, therapy of bone tumors will also be shortly discussed. In the end, several curative and palliative methods of interventional radiology will be talked about- cementoplasty, alcohol ablation and thermal ablation, as well as indications and contraindication for the same.