Menopausal transition is a natural phase in a woman's life in which her body undergoes hormonal changes that ultimately lead to the cessation of menstruation, and thus mark the end of the reproductive phase of her life. During this period, women often experience a variety of symptoms, including hot flashes, night sweats, mood swings, insomnia, vaginal dryness, and decreased libido. Although these symptoms vary in intensity and duration, they can significantly affect their quality of life. Many women seek relief from these symptoms through a variety of treatment options, including hormone replacement therapy, nonhormonal therapy and lifestyle changes. Hormone replacement therapy is considered to be the first line of therapy for menopausal symptoms, however, many women turn to other therapy options due to various health risks, contraindications, and potential adverse effects of HRT.Recently, there has been an increasing demand for natural alternatives to hormone therapy, especially for the use of nutritional supplements to alleviate the symptoms of menopause. Such supplements are readily available over the counter in various combinations and forms. The most commonly used dietary supplements are soy isoflavones, black cohosh, evening primrose oil, ginseng, vitamin E, valerian, hops and others. Despite their popularity, the scientific evidence supporting these preparations is often mixed and lacking. Some studies show promising results, suggesting that certain dietary supplements can help alleviate specific symptoms, such as the alleviation of vasomotor disturbances when using soy isoflavones. The others are not of sufficient volume and specificity to finally prove the effectiveness of individual supplements. Although there are still many unknowns related to the effectiveness of nutritional supplements in the treatment of menopausal problems, they justifiably form a valuable basis for further scientific research into natural alternative methods of treatment.