In 2019, the whole world, including Croatia, was faced with a new strain of coronavirus that caused the disease COVID-19, which resulted in the reorganization of the entire health system at all levels of health care. This work will present the daily work of nurses/technicians in family medicine offices during 2019 and during the epidemic of the COVID-19 disease. The sample of respondents consisted of 22 nurses employed in a family medicine practice within the Zagreb-Zapad Health Center in the age group of 18-65 years. The instrument was a questionnaire created for the purposes of this research. The first part of the questionnaire collected general information about the respondents such as gender, age, professional qualification, and the second part tried to show the scope of administrative work in relation to nursing professional skills and the activities of nurses through the roles of practitioner, educator, counselor, lawyer, manager, leader , agents of change and leaders and/or members of the research team in the family medicine team during the COVID-19 epidemic compared to 2019. The obtained results show that in 2019, administrative work took up more than half of the working time of the largest number of respondents on average, that is, it took up time equally in relation to nursing professional skills. During the epidemic, for the largest number of respondents, administrative work took on average most of their working time compared to nursing professional skills. The examination did not establish the presence of a statistically significant difference in the scope of administrative work in relation to nursing professional skills with regard to the period. The median value of the nurse's action as a representative of change was higher during the epidemic compared to the median value during 2019, and the presence of a statistically significant difference was determined. The presence of statistically significant differences was not found in the case of other activities.