prikaz prve stranice dokumenta Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment
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Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment
Biomedicines, 11 (2023), 2; 235. https://doi.org/10.3390/biomedicines11020235
Kouter, Katarina; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Miloš, Tina; Tudor, Lucija; Uzun, Suzana; Mimica, Ninoslav; Pivac, Nela; Videtič Paska, Alja

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Kouter, K., Nikolac Perković, M., Nedić Erjavec, G., Miloš, T., Tudor, L., Uzun, S. ... Videtič Paska, A. (2023). Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment. Biomedicines, 11. (2). doi: 10.3390/biomedicines11020235

Kouter, Katarina, et al. "Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment." Biomedicines, vol. 11, br. 2, 2023. https://doi.org/10.3390/biomedicines11020235

Kouter, Katarina, Matea Nikolac Perković, Gordana Nedić Erjavec, Tina Miloš, Lucija Tudor, Suzana Uzun, Ninoslav Mimica, Nela Pivac i Alja Videtič Paska. "Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment." Biomedicines 11, br. 2 (2023). https://doi.org/10.3390/biomedicines11020235

Kouter, K., et al. (2023) 'Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment', Biomedicines, 11(2). doi: 10.3390/biomedicines11020235

Kouter K, Nikolac Perković M, Nedić Erjavec G, Miloš T, Tudor L, Uzun S, i sur.. Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment. Biomedicines [Internet]. 17.01.2023. [pristupljeno 22.11.2024.];11(2). doi: 10.3390/biomedicines11020235

K. Kouter, et al., "Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment", Biomedicines, vol. 11, br. 2, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:205007. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:205007
Podaci o radu
Naslov (engleski)Difference in Methylation and Expression of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Mild Cognitive Impairment
AutorKatarina Kouter
AutorMatea Nikolac Perković
AutorGordana Nedić Erjavec
AutorTina Miloš
AutorLucija Tudor
AutorSuzana Uzun
AutorNinoslav Mimica
AutorNela Pivac
AutorAlja Videtič Paska
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Due to the increasing number of progressive dementias in the population, numerous studies are being conducted that seek to determine risk factors, biomarkers and pathological mechanisms that could help to differentiate between normal symptoms of aging, mild cognitive impairment (MCI) and dementia. The aim of this study was to investigate the possible association of levels of BDNF and COMT gene expression and methylation in peripheral blood cells with the development of Alzheimer’s disease (AD). Our results revealed higher expression levels of BDNF (p < 0.001) in MCI subjects compared to individuals diagnosed with AD. However, no difference in COMT gene expression (p = 0.366) was detected. DNA methylation of the CpG islands and other sequences with potential effects on gene expression regulation revealed just one region (BDNF_9) in the BDNF gene (p = 0.078) with marginally lower levels of methylation in the AD compared to MCI subjects. Here, we show that the level of BDNF expression in the periphery is decreased in subjects with AD compared to individuals with MCI. The combined results from the gene expression analysis and DNA methylation analysis point to the potential of BDNF as a marker that could help distinguish between MCI and AD patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 11, br. 2, 235
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11020235
URN:NBNurn:nbn:hr:105:205007
Datum objave publikacije2023-01-17
URL dokumentahttps://www.mdpi.com/2227-9059/11/2/235
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-15 08:47:03