Introduction and aim of the research: Peripheral neuropathy is one of the most common side effects of taxane cytotoxic drugs in the treatment of early stage breast cancer. By its action, it can be the cause of hand and foot dysfunction and thus affect daily activities, reduce the quality of life and change the course of treatment. Recording of peripheral neuropathy is limited to patients who self-report subjective symptoms to their healthcare team. Physical activity has significant effects on the reduction and prevention of peripheral neuropathy caused by chemotherapy. The aim of this work was to examine the relationship between physical activity and the incidence of neuropathy in breast cancer patients. The hypothesis of the work is "physical activity significantly affects the reduced incidence of neuropathy in patients treated with chemotherapy with taxanes who take an average of more than 10,000 steps per day." Subjects and methods: Longitudinal research was conducted on a convenient sample of subjects (n=32) in the Outpatient Care, Clinic for Oncology, Clinical Hospital Center Zagreb. For the purpose of conducting the research, data on daily and weekly average physical activity measured by the Pedometer mobile application while awake were collected for each individual patient. Results: The research showed a statistically significant difference was recorded in the number of steps and the dose of the drug with regard to the observed treatment cycles, with a confidence level of 95 % (P= 0.001, P= 0.000), while the values of these variables began to decrease in the last periods treatment (after the 7th cycle), however, a statistically significant correlation between the variables steps and drug dose (P > 0.05) was not observed, nor was there a correlation between the number of steps and the incidence of neuropathy itself (P>0.05). The analysis of the mutual correlation of dose reduction and neuropathy is less than 0.05 (P<0.05), which indicates that a statistically significant difference was observed with regard to the total value of steps, confirming the thesis that physically active patients did not have a dose reduction due to neuropathy. Conclusion: The results showed that in the sample of examined patients, physical activity as well as the reduction of initial drug doses decreased after the middle of the cycle (7th cycle). Although the doses are reduced, it has been shown that physical activity is not closely related to the incidence of neuropathy itself, but physically active patients have less dose reduction due to the appearance of neuropathy compared to patients with reduced physical activity.