Sexuality is an important aspect of human functioning and is influenced by the interaction of many biological, psychosocial, spiritual, economic, political, and historical factors. Sexuality includes feelings about one's own body, the need for physical intimacy, the desire for sexual activity and communicating with partner(s) about sexual needs, as well as the ability to participate in sexual activities. All malignancies including gynecological cancers such as ovarian and fallopian tube cancers, cervical and trunk cancers, vaginal cancers, and vulvar cancers affect person's intimacy and sexuality. Cancer treatments often lead to sexual dysfunction. Sexual dysfunction is a disorder of any of the partners during any phase of sexual activity that can manifest itself as loss of sexual desire, sexual arousal disorders, difficulty to reach orgasm, and pain-related disorders (vaginismus and dyspareunia). Treatments for gynecological cancers most often include surgery, chemotherapy, radiation, and hormonal therapy. Any of the above forms of treatment can leave temporary or permanent adverse effects on sexuality including experiencing feelings such as anger, fear, anxiety, sadness, and the like. It can affect the production and secretion of hormones necessary for pleasant sexual intercourse, a person's physical ability to feel sexual pleasure, the positive image of their own body, and fulfilling emotional relationships with partner(s). The aim of this paper is to systematically review the relevant literature examining sexuality and difficulties faced by patients with gynecological cancer; to understand how much the diagnosis and treatment procedures affect sexual satisfaction and the overall quality of life.