prikaz prve stranice dokumenta Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep
  Preuzmi
PDF 16.47 MB
Znanstveni rad - Izvorni znanstveni rad
Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep
Scientific Reports, 13 (2023), 1; 22079. https://doi.org/10.1038/s41598-023-48878-9
Ivanjko, Natalia; Štoković, Nikola; Pećin, Marko; Vnuk, Dražen; Smajlović, Ana; Ivkić, Niko; Capak, Hrvoje; Javor, Ana; Vrbanac, Zoran; Matičić, Dražen; Vukičević, Slobodan

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Ivanjko, N., Štoković, N., Pećin, M., Vnuk, D., Smajlović, A., Ivkić, N. ... Vukičević, S. (2023). Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep. Scientific Reports, 13. (1). doi: 10.1038/s41598-023-48878-9

Ivanjko, Natalia, et al. "Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep." Scientific Reports, vol. 13, br. 1, 2023. https://doi.org/10.1038/s41598-023-48878-9

Ivanjko, Natalia, Nikola Štoković, Marko Pećin, Dražen Vnuk, Ana Smajlović, Niko Ivkić, Hrvoje Capak, et al. "Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep." Scientific Reports 13, br. 1 (2023). https://doi.org/10.1038/s41598-023-48878-9

Ivanjko, N., et al. (2023) 'Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep', Scientific Reports, 13(1). doi: 10.1038/s41598-023-48878-9

Ivanjko N, Štoković N, Pećin M, Vnuk D, Smajlović A, Ivkić N, i sur.. Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep. Scientific Reports [Internet]. 12.12.2023. [pristupljeno 29.12.2024.];13(1). doi: 10.1038/s41598-023-48878-9

N. Ivanjko, et al., "Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep", Scientific Reports, vol. 13, br. 1, Prosinac 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:755985. [Citirano: 29.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:755985
Podaci o radu
Naslov (engleski)Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep
AutorNatalia Ivanjko
AutorNikola Štoković
AutorMarko Pećin
AutorDražen Vnuk
AutorAna Smajlović
AutorNiko Ivkić
AutorHrvoje Capak
AutorAna Javor
AutorZoran Vrbanac
AutorDražen Matičić
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Posterolateral spinal fusion (PLF) is a procedure used for the treatment of degenerative spine disease. In this study we evaluated Osteogrow-C, a novel osteoinductive device comprised of recombinant human Bone morphogenetic protein 6 (rhBMP6) dispersed in autologous blood coagulum with synthetic ceramic particles, in the sheep PLF model. Osteogrow-C implants containing 74-420 or 1000-1700 µm ceramic particles (TCP/HA 80/20) were implanted between L4-L5 transverse processes in sheep (Ovis Aries, Merinolaandschaf breed). In the first experiment (n = 9 sheep; rhBMP6 dose 800 µg) the follow-up period was 27 weeks while in the second experiment (n = 12 sheep; rhBMP6 dose 500 µg) spinal fusion was assessed by in vivo CT after 9 weeks and at the end of the experiment after 14 (n = 6 sheep) and 40 (n = 6 sheep) weeks. Methods of evaluation included microCT, histological analyses and biomechanical testing. Osteogrow-C implants containing both 74-420 and 1000-1700 µm ceramic particles induced radiographic solid fusion 9 weeks following implantation. Ex-vivo microCT and histological analyses revealed complete osseointegration of newly formed bone with adjacent transverse processes. Biomechanical testing confirmed that fusion between transverse processes was complete and successful. Osteogrow-C implants induced spinal fusion in sheep PLF model and therefore represent a novel therapeutic solution for patients with degenerative disc disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 13, br. 1, 22079
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-023-48878-9
URN:NBNurn:nbn:hr:105:755985
Datum objave publikacije2023-12-12
URL dokumentahttps://www.nature.com/articles/s41598-023-48878-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-03-05 08:33:27