prikaz prve stranice dokumenta Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking
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Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking
Neuroscience Letters, 520 (2012), 1; 67-70. https://doi.org/10.1016/j.neulet.2012.05.032
Babić, Mirjana; Nedić, Gordana; Muck-Šeler, Dorotea; Borovečki, Fran; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Babić, M., Nedić, G., Muck Šeler, D., Borovečki, F. i Pivac, N. (2012). Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking. Neuroscience Letters, 520. (1), 67-70. doi: 10.1016/j.neulet.2012.05.032

Babić, Mirjana, et al. "Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking." Neuroscience Letters, vol. 520, br. 1, 2012, str. 67-70. https://doi.org/10.1016/j.neulet.2012.05.032

Babić, Mirjana, Gordana Nedić, Dorotea Muck Šeler, Fran Borovečki i Nela Pivac. "Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking." Neuroscience Letters 520, br. 1 (2012): 67-70. https://doi.org/10.1016/j.neulet.2012.05.032

Babić, M., et al. (2012) 'Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking', Neuroscience Letters, 520(1), str. 67-70. doi: 10.1016/j.neulet.2012.05.032

Babić M, Nedić G, Muck Šeler D, Borovečki F, Pivac N. Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking. Neuroscience Letters [Internet]. 27.06.2012. [pristupljeno 28.04.2024.];520(1):67-70. doi: 10.1016/j.neulet.2012.05.032

M. Babić, G. Nedić, D. Muck Šeler, F. Borovečki i N. Pivac, "Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking", Neuroscience Letters, vol. 520, br. 1, str. 67-70, Lipanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:306340. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:306340
Podaci o radu
Naslov (engleski)Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking
AutorMirjana Babić
AutorGordana Nedić
AutorDorotea Muck-Šeler
AutorFran Borovečki
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Nicotine addiction, related to cigarette smoking, develops as a product of the complex interactions between social, environmental and genetic factors. Genes encoding the components of the dopaminergic system are thought to be associated with smoking. Literature data showed not only an association, but also a lack of association between variable number of tandem repeats (VNTR) polymorphism located in the third exon of dopamine D4 receptor (DRD4) gene and smoking. Repetitive sequence of DRD4 VNTR is 48 bp long and maximum 11 tandem copies were reported in humans. Presence of alleles with 6 and more repeats (i.e. long alleles) was associated with greater tendency to novelty seeking and addictive behaviors than the presence of 5 and less alleles (short alleles). The aim of this study was to determine the association between VNTR in DRD4 gene and present smoking status in ethnically homogenous Caucasian population from the Eastern European (Croatian) origin. Genotyping was done in 565 healthy subjects, 511 men and 54 women, respectively, who were subdivided into 176 smokers and 389 nonsmokers. Logistic regression analyses, adjusted for age and sex, revealed the lack of significant (p>0.05) effect of the 4/4, 4/7 and 7/7 genotypes, or carriers of the long and short allele, or all genotypes of the DRD4 VNTR on smoking status. The results of this study failed to confirm the hypothesis that long allele of the DRD4 VNTR is associated with smoking status in Caucasian subjects.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaNeuroscience Letters
Brojčani podacivol. 520, br. 1, str. 67-70
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2012.05.032
URN:NBNurn:nbn:hr:105:306340
Datum objave publikacije2012-06-27
URL dokumentahttps://doi.org/10.1016/j.neulet.2012.05.032
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 19:31:04