prikaz prve stranice dokumenta Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation
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Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation
Toxicology in Vitro, 27 (2013), 2; 523-532. https://doi.org/10.1016/j.tiv.2012.11.003
Rak, Sanjica; Čimbora-Zovko, Tamara; Gajski, Goran; Dubravčić, Klara; Domijan, Ana-Marija; Delaš, Ivančica; Garaj-Vrhovac, Verica; Batinić, Drago; Sorić, Jasna; Osmak, Maja

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Rak, S., Čimbora Zovko, T., Gajski, G., Dubravčić, K., Domijan, A. M., Delaš, I. ... Osmak, M. (2013). Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation. Toxicology in Vitro, 27. (2), 523-532. doi: 10.1016/j.tiv.2012.11.003

Rak, Sanjica, et al. "Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation." Toxicology in Vitro, vol. 27, br. 2, 2013, str. 523-532. https://doi.org/10.1016/j.tiv.2012.11.003

Rak, Sanjica, Tamara Čimbora Zovko, Goran Gajski, Klara Dubravčić, Ana Marija Domijan, Ivančica Delaš, Verica Garaj Vrhovac, Drago Batinić, Jasna Sorić i Maja Osmak. "Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation." Toxicology in Vitro 27, br. 2 (2013): 523-532. https://doi.org/10.1016/j.tiv.2012.11.003

Rak, S., et al. (2013) 'Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation', Toxicology in Vitro, 27(2), str. 523-532. doi: 10.1016/j.tiv.2012.11.003

Rak S, Čimbora Zovko T, Gajski G, Dubravčić K, Domijan AM, Delaš I, i sur.. Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation. Toxicology in Vitro [Internet]. 03.2013. [pristupljeno 27.12.2024.];27(2):523-532. doi: 10.1016/j.tiv.2012.11.003

S. Rak, et al., "Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation", Toxicology in Vitro, vol. 27, br. 2, str. 523-532, Ožujak 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:395887. [Citirano: 27.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:395887
Podaci o radu
Naslov (engleski)Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation
AutorSanjica Rak
AutorTamara Čimbora-Zovko
AutorGoran Gajski
AutorKlara Dubravčić
AutorAna-Marija Domijan
AutorIvančica Delaš
AutorVerica Garaj-Vrhovac
AutorDrago Batinić
AutorJasna Sorić
AutorMaja Osmak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Curcumin is a natural compound that exhibits a wide range of beneficial effects, among them the anti-tumor activity. Recently it was shown that curcumin may be efficient against drug resistant tumor cells. The goal of our investigation was to examine if human laryngeal carcinoma cells resistant to carboplatin display sensitivity to curcumin, as compared to parental cells, and if this sensitivity is altered, to determine the molecular mechanisms that are responsible for it. We found that carboplatin resistant 7T cells were also cross resistant to curcumin. After the treatment with equimolar concentration of curcumin, 7T cells exhibited lower intracellular accumulation of curcumin which coincided with reduced formation of reactive oxygen species (ROS), diminished lipid and DNA damage followed by reduced induction of apoptosis and expression of heat shock protein 70 (Hsp70), as compared to parental HEp-2 cells. However, after the treatment with equitoxic concentration of curcumin, intracellular accumulation and all the explored downstream effects were similar in both cell lines suggesting that resistance of 7T cells to curcumin was based on its reduced intracellular accumulation. Since curcumin accumulates mostly in the membranes, we explored the fatty acid composition of both cell lines, but we did not find any difference between them.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaToxicology in Vitro
Brojčani podacivol. 27, br. 2, str. 523-532
p-ISSN0887-2333
DOIhttps://doi.org/10.1016/j.tiv.2012.11.003
URN:NBNurn:nbn:hr:105:395887
Datum objave publikacije2013-03
URL dokumentahttps://doi.org/10.1016/j.tiv.2012.11.003
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:43:51