prikaz prve stranice dokumenta Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability
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Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability
Journal of Physiology and Pharmacology, 64 (2013), 5; 597-612. urn:nbn:hr:105:280120
Kliček, Robert; Kolenc, Danijela; Šuran, Jelena; Drmić, Domagoj; Brčić, Luka; Aralica, Gorana; Sever, Marko; Holjevac, J.; Radić, Božo; Turudić, Tanja; Kokot, A.; Patrlj, Leonardo; Rucman, Rudolf; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Kliček, R., Kolenc, D., Šuran, J., Drmić, D., Brčić, L., Aralica, G. ... Sikirić, P. (2013). Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. Journal of Physiology and Pharmacology, 64. (5), 597-612. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:280120

Kliček, Robert, et al. "Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability." Journal of Physiology and Pharmacology, vol. 64, br. 5, 2013, str. 597-612. https://urn.nsk.hr/urn:nbn:hr:105:280120

Kliček, Robert, Danijela Kolenc, Jelena Šuran, Domagoj Drmić, Luka Brčić, Gorana Aralica, Marko Sever, et al. "Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability." Journal of Physiology and Pharmacology 64, br. 5 (2013): 597-612. https://urn.nsk.hr/urn:nbn:hr:105:280120

Kliček, R., et al. (2013) 'Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability', Journal of Physiology and Pharmacology, 64(5), str. 597-612. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:280120 (Datum pristupa: 05.11.2024.)

Kliček R, Kolenc D, Šuran J, Drmić D, Brčić L, Aralica G, i sur.. Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. Journal of Physiology and Pharmacology [Internet]. 10.2013. [pristupljeno 05.11.2024.];64(5):597-612. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:280120

R. Kliček, et al., "Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability", Journal of Physiology and Pharmacology, vol. 64, br. 5, str. 597-612, Listopad 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:280120. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:280120
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Naslov (engleski)Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability
AutorRobert Kliček
AutorDanijela Kolenc
AutorJelena Šuran
AutorDomagoj Drmić
AutorLuka Brčić
AutorGorana Aralica
AutorMarko Sever
AutorJ. Holjevac
AutorBožo Radić
AutorTanja Turudić
AutorA. Kokot
AutorLeonardo Patrlj
AutorRudolf Rucman
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Stable gastric pentadecapeptide BPC 157 was suggested to link inflammatory bowel disease and multiple sclerosis, and thereby, shown to equally counteract the models of both of those diseases. For colitis, cysteamine (400 mg/kg intrarectally (1 ml/rat)) and colon-colon anastomosis (sacrifice at day 3, 5, 7, and 14) were used. BPC 157 (10 μg/kg, 10 ng/kg) was applied either intraperitoneally once time daily (first application immediately after surgery, last at 24 hours before sacrifice) or per-orally in drinking water (0.16 μg/ml/12 ml/day till the sacrifice) while controls simultaneously received an equivolume of saline (5 ml/kg) intraperitoneally or drinking water only (12 ml/day). A multiple sclerosis suited toxic rat model, cuprizone (compared with standard, a several times higher regimen, 2.5% of diet regimen + 1 g/kg intragastrically/day) was combined with BPC 157 (in drinking water 0.16 μg or 0.16 ng/ml/12 ml/day/rat + 10 μg or 10 ng/kg intragastrically/day) till the sacrifice at day 4. In general, the controls could not heal cysteamine colitis and colon-colon anastomosis. BPC 157 induced an efficient healing of both at the same time. Likewise, cuprizone-controls clearly exhibited an exaggerated and accelerated damaging process; nerve damage appeared in various brain areas, with most prominent damage in corpus callosum, laterodorsal thalamus, nucleus reunions, anterior horn motor neurons. BPC 157-cuprizone rats had consistently less nerve damage in all damaged areas, especially in those areas that otherwise were most affected. Consistently, BPC 157 counteracted cerebellar ataxia and impaired forelimb function. Thereby, this experimental evidence advocates BPC 157 in both inflammatory bowel disease and multiple sclerosis therapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Physiology and Pharmacology
Brojčani podacivol. 64, br. 5, str. 597-612
p-ISSN0867-5910
URN:NBNurn:nbn:hr:105:280120
Datum objave publikacije2013-10
URL dokumentahttp://www.jpp.krakow.pl/journal/archive/10_13/pdf/597_10_13_article.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:01:29