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An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
Bioorganic & Medicinal Chemistry, 20 (2012), 10; 3180-3185. https://doi.org/10.1016/j.bmc.2012.03.074
Verbanac, Donatella; Jain, Subhash C.; Jain, Nidhi; Chand, Mahesh; Čipčić Paljetak, Hana; Matijašić, Mario; Perić, Mihaela; Stepanić, Višnja; Saso, Luciano

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Verbanac, D., Jain, S. C., Jain, N., Chand, M., Čipčić Paljetak, H., Matijašić, M. ... Saso, L. (2012). An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. Bioorganic & Medicinal Chemistry, 20. (10), 3180-3185. doi: 10.1016/j.bmc.2012.03.074

Verbanac, Donatella, et al. "An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization." Bioorganic & Medicinal Chemistry, vol. 20, br. 10, 2012, str. 3180-3185. https://doi.org/10.1016/j.bmc.2012.03.074

Verbanac, Donatella, Subhash C. Jain, Nidhi Jain, Mahesh Chand, Hana Čipčić Paljetak, Mario Matijašić, Mihaela Perić, Višnja Stepanić i Luciano Saso. "An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization." Bioorganic & Medicinal Chemistry 20, br. 10 (2012): 3180-3185. https://doi.org/10.1016/j.bmc.2012.03.074

Verbanac, D., et al. (2012) 'An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization', Bioorganic & Medicinal Chemistry, 20(10), str. 3180-3185. doi: 10.1016/j.bmc.2012.03.074

Verbanac D, Jain SC, Jain N, Chand M, Čipčić Paljetak H, Matijašić M, i sur.. An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. Bioorganic & Medicinal Chemistry [Internet]. 15.05.2012. [pristupljeno 22.11.2024.];20(10):3180-3185. doi: 10.1016/j.bmc.2012.03.074

D. Verbanac, et al., "An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization", Bioorganic & Medicinal Chemistry, vol. 20, br. 10, str. 3180-3185, Svibanj 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:669055. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:669055
Podaci o radu
Naslov (engleski)An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
AutorDonatella Verbanac
AutorSubhash C. Jain
AutorNidhi Jain
AutorMahesh Chand
AutorHana Čipčić Paljetak
AutorMario Matijašić
AutorMihaela Perić
AutorVišnja Stepanić
AutorLuciano Saso
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Xanthones and their thio-derivatives are a class of pleiotropic compounds with various reported pharmacological and biological activities. Although these activities are mainly determined in laboratory conditions, the class itself has a great potential to be utilized as promising chemical scaffold for the synthesis of new drug candidates. One of the main obstacles in utilization of these compounds was related to the difficulties in their chemical synthesis. Most of the known methods require two steps, and are limited to specific reagents not applicable to a large number of starting materials. In this paper a new and improved method for chemical synthesis of xanthones is presented. By applying a new procedure, we have successfully obtained these compounds with the desired regioselectivity in a shorter reaction time (50s) and with better yield (>80%). Finally, the preliminary in vitro screenings on different bacterial species and cytotoxicity assessment, as well as in silico activity evaluation were performed. The obtained results confirm potential pharmacological use of this class of molecules.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaBioorganic & Medicinal Chemistry
Brojčani podacivol. 20, br. 10, str. 3180-3185
p-ISSN0968-0896
DOIhttps://doi.org/10.1016/j.bmc.2012.03.074
URN:NBNurn:nbn:hr:105:669055
Datum objave publikacije2012-05-15
URL dokumentahttps://doi.org/10.1016/j.bmc.2012.03.074
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:03:26