prikaz prve stranice dokumenta Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial
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Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial
Medical Science Monitor, 21 (2015); 2406-2413. https://doi.org/10.12659/MSM.893881
Kozić Dokmanović, Sanja; Kolovrat, Krunoslava; Laškaj, Renata; Jukić, Vedrana; Vrkić, Nada; Begovac, Josip

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Kozić Dokmanović, S., Kolovrat, K., Laškaj, R., Jukić, V., Vrkić, N. i Begovac, J. (2015). Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial. Medical Science Monitor, 21., 2406-2413. doi: 10.12659/MSM.893881

Kozić Dokmanović, Sanja, et al. "Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial." Medical Science Monitor, vol. 21, 2015, str. 2406-2413. https://doi.org/10.12659/MSM.893881

Kozić Dokmanović, Sanja, Krunoslava Kolovrat, Renata Laškaj, Vedrana Jukić, Nada Vrkić i Josip Begovac. "Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial." Medical Science Monitor 21 (2015): 2406-2413. https://doi.org/10.12659/MSM.893881

Kozić Dokmanović, S., et al. (2015) 'Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial', Medical Science Monitor, 21, str. 2406-2413. doi: 10.12659/MSM.893881

Kozić Dokmanović S, Kolovrat K, Laškaj R, Jukić V, Vrkić N, Begovac J. Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial. Medical Science Monitor [Internet]. 2015. [pristupljeno 09.05.2024.];21:2406-2413. doi: 10.12659/MSM.893881

S. Kozić Dokmanović, K. Kolovrat, R. Laškaj, V. Jukić, N. Vrkić i J. Begovac, "Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial", Medical Science Monitor, vol. 21, str. 2406-2413, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:838117. [Citirano: 09.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:838117
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Naslov (engleski)Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial
AutorSanja Kozić Dokmanović
AutorKrunoslava Kolovrat
AutorRenata Laškaj
AutorVedrana Jukić
AutorNada Vrkić
AutorJosip Begovac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART. ----- MATERIAL AND METHODS: This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively. ----- RESULTS: In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration. ----- CONCLUSIONS: Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical Science Monitor
Brojčani podacivol. 21, str. 2406-2413
p-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.893881
URN:NBNurn:nbn:hr:105:838117
Datum objave publikacije2015
URL dokumentahttps://doi.org/10.12659/MSM.893881
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:34:34