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Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease
Croatian Medical Journal, 57 (2016), 3; 276-286. https://doi.org/10.3325/cmj.2016.57.276
Katić, Mašenjka; Pirsl, Filip; Steinberg, Seth M.; Dobbin, Marnie; Curtis, Lauren M.; Pulanić, Dražen; Desnica, Lana; Titarenko, Irina; Pavletic, Steven Z.

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Katić, M., Pirsl, F., Steinberg, S. M., Dobbin, M., Curtis, L. M., Pulanić, D. ... Pavletic, S. Z. (2016). Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease. Croatian Medical Journal, 57. (3), 276-286. doi: 10.3325/cmj.2016.57.276

Katić, Mašenjka, et al. "Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal, vol. 57, br. 3, 2016, str. 276-286. https://doi.org/10.3325/cmj.2016.57.276

Katić, Mašenjka, Filip Pirsl, Seth M. Steinberg, Marnie Dobbin, Lauren M. Curtis, Dražen Pulanić, Lana Desnica, Irina Titarenko i Steven Z. Pavletic. "Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease." Croatian Medical Journal 57, br. 3 (2016): 276-286. https://doi.org/10.3325/cmj.2016.57.276

Katić, M., et al. (2016) 'Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease', Croatian Medical Journal, 57(3), str. 276-286. doi: 10.3325/cmj.2016.57.276

Katić M, Pirsl F, Steinberg SM, Dobbin M, Curtis LM, Pulanić D, i sur.. Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease. Croatian Medical Journal [Internet]. 06.2016. [pristupljeno 09.11.2024.];57(3):276-286. doi: 10.3325/cmj.2016.57.276

M. Katić, et al., "Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease", Croatian Medical Journal, vol. 57, br. 3, str. 276-286, Lipanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:240453. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:240453
Podaci o radu
Naslov (engleski)Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease
AutorMašenjka Katić
AutorFilip Pirsl
AutorSeth M. Steinberg
AutorMarnie Dobbin
AutorLauren M. Curtis
AutorDražen Pulanić
AutorLana Desnica
AutorIrina Titarenko
AutorSteven Z. Pavletic
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To identify the factors associated with vitamin D status in patients with chronic graft-vs-host disease (cGVHD) and evaluate the association between serum vitamin D (25(OH)D) levels and cGVHD characteristics and clinical outcomes defined by the National Institutes of Health (NIH) criteria. ----- METHODS: 310 cGVHD patients enrolled in the NIH cGVHD natural history study (clinicaltrials.gov: NCT00092235) were analyzed. Univariate analysis and multiple logistic regression were used to determine the associations between various parameters and 25(OH)D levels, dichotomized into categorical variables: ≤20 and >20 ng/mL, and as a continuous parameter. Multiple logistic regression was used to develop a predictive model for low vitamin D. Survival analysis and association between cGVHD outcomes and 25(OH)D as a continuous as well as categorical variable: ≤20 and >20 ng/mL; <50 and ≥50 ng/mL, and among three ordered categories: ≤20, 20-50, and ≥50 ng/mL, was performed. ----- RESULTS: 69 patients (22.3%) had serum 25(OH)D ≤20 ng/mL. Univariate analysis showed that supplement intake, nutritional status (severely malnourished, moderately malnourished, well-nourished), race (African-American, other), and estimated creatinine clearance (eCCr) were associated with 25(OH)D levels. A predictive model was developed based on supplement intake, nutritional status, race, and eCCr, accurately predicting 77.9% of patients with 25(OH)D ≤20 and 65.2% of those with 25(OH)D >20 ng/mL. No association was found between vitamin D and major cGVHD characteristics, but patients with 25(OH)D ≤20 ng/mL had somewhat decreased survival. ----- CONCLUSION: Nutritional status and adequate supplementation are important to maintain 25(OH)D >20 ng/mL in cGVHD patients. Intervention studies and more research is needed to reveal the underlying mechanism of vitamin D metabolism in cGVHD setting.
Sažetak (hrvatski)
Razine vitamina D i njihova povezanost s preživljenjem i glavnim ishodima bolesti u velikoj skupini pacijenata s kroničnom bolešću presatka protiv domaćina ----- Cilj: Odrediti čimbenike koji su povezani s razinama vitamina D kod pacijenata s kroničnom bolešću presatka protiv domaćina (prema engl. chronic-graft-versus-host disease, cGVHD) i odrediti povezanost između serumskih razina vitamina D (25(OH)D) i obilježja cGVHD i kliničkih ishoda definiranih prema kriterijima Nacionalnih instituta za zdravlje SAD-a (prema engl. National Institutes of Health, NIH). ----- Postupci: Analizirali smo 310 pacijenata s cGVHD uključenih u NIH cGVHD studiju (clinicaltrials.gov: NCT00092235). Koristili smo univarijatnu analizu i multiplu logističku regresiju kako bi utvrdili povezanost između različitih parametara i razina 25(OH)D, dihotomiziranih kao kategorijska varijabla: ≤20 i >20 ng/mL i prikazanih kao kontinuirana varijabla. Multipla logistička regresija služila je razvijanju prediktivnog modela za niske vrijednosti vitamina D. Napravili smo analizu preživljenja i odredili povezanost između cGVHD ishoda i 25(OH)D kao kontinuirane ali i kao kategorijske varijable: ≤20 i >20 ng/mL; <50 i ≥50 ng/mL, i ≤20, 20-50 i ≥50 ng/mL. ----- Rezultati: 69 pacijenata (22,3%) imalo je serumski 25(OH)D ≤20 ng/mL. Univarijatna analiza pokazala je da su s razinama 25(OH)D bili povezani uzimanje dodataka prehrani, nutritivni status (iznimno pothranjen, umjereno pothranjen, dobro uhranjen), rasa (Afroamerikanci, ostali) i procijenjeni klirens kreatinina (prema engl. estimated creatinine clerance, eCCr). Razvili smo prediktivni model utemeljen na uzimanju dodataka prehrani, nutritivnom statusu, rasi i eCCr, koji je točno predvidio 77,9% pacijenata s 25(OH)D ≤20 i 65,2% pacijenata s 25(OH)D >20 ng/mL. Vitamin D nije bio povezan s glavnim obilježjima cGVHD, ali su pacijenti s 25(OH)D ≤20 ng/mL imali ponešto skraćeno preživljenje. ----- Zaključak: Nutritivni status i adekvatni dodaci prehrani važni su za održavanje 25(OH)D >20 ng/mL kod pacijenata s cGVHD. Potrebna su daljnja, posebice intervencijska, istraživanja kako bi se otkrili mehanizmi koji upravljaju metabolizmom vitamina D kod pacijenata s cGVHD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 57, br. 3, str. 276-286
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2016.57.276
URN:NBNurn:nbn:hr:105:240453
Datum objave publikacije2016-06
URL dokumentahttps://doi.org/10.3325/cmj.2016.57.276
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:44:04