prikaz prve stranice dokumenta Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats
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Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats
Neuroscience Letters, 617 (2016); 213-217. https://doi.org/10.1016/j.neulet.2016.02.020
Ibragić, Saida; Matak, Ivica; Dračić, Aida; Smajlović, Ahmed; Muminović, Mehmed; Proft, Florijan; Sofić, Emin; Lacković, Zdravko; Riederer, Peter

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Ibragić, S., Matak, I., Dračić, A., Smajlović, A., Muminović, M., Proft, F. ... Riederer, P. (2016). Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats. Neuroscience Letters, 617., 213-217. doi: 10.1016/j.neulet.2016.02.020

Ibragić, Saida, et al. "Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats." Neuroscience Letters, vol. 617, 2016, str. 213-217. https://doi.org/10.1016/j.neulet.2016.02.020

Ibragić, Saida, Ivica Matak, Aida Dračić, Ahmed Smajlović, Mehmed Muminović, Florijan Proft, Emin Sofić, Zdravko Lacković i Peter Riederer. "Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats." Neuroscience Letters 617 (2016): 213-217. https://doi.org/10.1016/j.neulet.2016.02.020

Ibragić, S., et al. (2016) 'Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats', Neuroscience Letters, 617, str. 213-217. doi: 10.1016/j.neulet.2016.02.020

Ibragić S, Matak I, Dračić A, Smajlović A, Muminović M, Proft F, i sur.. Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats. Neuroscience Letters [Internet]. 23.03.2016. [pristupljeno 14.05.2024.];617:213-217. doi: 10.1016/j.neulet.2016.02.020

S. Ibragić, et al., "Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats", Neuroscience Letters, vol. 617, str. 213-217, Ožujak 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:820906. [Citirano: 14.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:820906
Podaci o radu
Naslov (engleski)Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats
AutorSaida Ibragić
AutorIvica Matak
AutorAida Dračić
AutorAhmed Smajlović
AutorMehmed Muminović
AutorFlorijan Proft
AutorEmin Sofić
AutorZdravko Lacković
AutorPeter Riederer
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Despite its toxicity, botulinum neurotoxin type A (BTX-A) is a valuable therapeutic agent for several motor, autonomic and pain disorders. Numerous studies have described its peripheral as well as central effects. Using reversed-phase High Performance Liquid Chromatography with Electrochemical Detection (HPLC-ED) and gradient elution, we quantified the concentrations of dopamine (DA), noradrenaline (NA), serotonin (5-HT) and their metabolites in 10 brain regions, ipsilateral and contralateral from the site of unilateral BTX-A administration (5 U/kg) into the rat whisker pad. In regions associated with nociception and pain processing we also examined possible BTX-A effects in combination with formalin-induced inflammatory orofacial pain. The dominant BTX-A effects on the monoamines and their metabolites were insignificant. The only significant increase caused by BTX-A alone was that of NA in striatum and serotonin in hypothalamus. While antinociceptive effects of BTX-A are most probably not related to central monoamine concentrations, the localized increased NA and 5-HT concentrations might play a role in reported BTX-A efficacy for the treatment of depression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaNeuroscience Letters
Brojčani podacivol. 617, str. 213-217
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2016.02.020
URN:NBNurn:nbn:hr:105:820906
Datum objave publikacije2016-03-23
URL dokumentahttps://doi.org/10.1016/j.neulet.2016.02.020
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:57:17