prikaz prve stranice dokumenta Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease
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Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease
Drugs & Aging, 33 (2016), 11; 787-808. https://doi.org/10.1007/s40266-016-0407-9
Osmanović-Barilar, Jelena; Šalković-Petrišić, Melita

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Osmanović Barilar, J. i Šalković Petrišić, M. (2016). Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease. Drugs & Aging, 33. (11), 787-808. doi: 10.1007/s40266-016-0407-9

Osmanović Barilar, Jelena i Melita Šalković Petrišić. "Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease." Drugs & Aging, vol. 33, br. 11, 2016, str. 787-808. https://doi.org/10.1007/s40266-016-0407-9

Osmanović Barilar, Jelena i Melita Šalković Petrišić. "Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease." Drugs & Aging 33, br. 11 (2016): 787-808. https://doi.org/10.1007/s40266-016-0407-9

Osmanović Barilar, J. i Šalković Petrišić, M. (2016) 'Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease', Drugs & Aging, 33(11), str. 787-808. doi: 10.1007/s40266-016-0407-9

Osmanović Barilar J, Šalković Petrišić M. Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease. Drugs & Aging [Internet]. 11.2016. [pristupljeno 15.05.2024.];33(11):787-808. doi: 10.1007/s40266-016-0407-9

J. Osmanović Barilar i M. Šalković Petrišić, "Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease", Drugs & Aging, vol. 33, br. 11, str. 787-808, Studeni 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:631932. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:631932
Podaci o radu
Naslov (engleski)Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease
AutorJelena Osmanović-Barilar
AutorMelita Šalković-Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Hormone therapy (HT) is prescribed during or after menopausal transition to replace the decline in estrogen and progesterone levels. While some studies indicate that estrogen and progesterone depletion in postmenopausal women might carry a significant risk for developing sporadic Alzheimer's disease (sAD), which may be reduced by HT, recent clinical trials oppose this beneficial effect. This review points to possible reasons for these mixed data by considering the issues of both preclinical and clinical trials, in particular, the representativeness of animal models, timing of HT initiation, type of HT (different types of estrogen compounds, estrogen monotherapy vs. estrogen-progesterone combined therapy), mode of drug delivery (subcutaneous, transdermal, oral, or intramuscular), and hormone dosage used, as well as the heterogeneity of the postmenopausal population in clinical trials (particularly considering their sAD stage, anti-AD therapy, and hysterectomy status). Careful planning of future preclinical and clinical HT interventional studies might help to elucidate the effect of HT on cognitive status in postmenopausal women with sAD, which will eventually contribute to more effective sAD prevention and treatment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaDrugs & Aging
Brojčani podacivol. 33, br. 11, str. 787-808
p-ISSN1170-229X
DOIhttps://doi.org/10.1007/s40266-016-0407-9
URN:NBNurn:nbn:hr:105:631932
Datum objave publikacije2016-11
URL dokumentahttps://doi.org/10.1007/s40266-016-0407-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:59:54