prikaz prve stranice dokumenta A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment
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A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment
Psychopharmacology, 233 (2016), 17; 3259-3267. https://doi.org/10.1007/s00213-016-4364-0
Šagud, Marina; Nikolac Perković, Matea; Vuksan-Ćusa, Bjanka; Maravić, Anja; Švob Štrac, Dubravka; Mihaljević Peleš, Alma; Živković, Maja; Kušević, Zorana; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Šagud, M., Nikolac Perković, M., Vuksan Ćusa, B., Maravić, A., Švob Štrac, D., Mihaljević Peleš, A. ... Pivac, N. (2016). A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology, 233. (17), 3259-3267. doi: 10.1007/s00213-016-4364-0

Šagud, Marina, et al. "A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment." Psychopharmacology, vol. 233, br. 17, 2016, str. 3259-3267. https://doi.org/10.1007/s00213-016-4364-0

Šagud, Marina, Matea Nikolac Perković, Bjanka Vuksan Ćusa, Anja Maravić, Dubravka Švob Štrac, Alma Mihaljević Peleš, Maja Živković, Zorana Kušević i Nela Pivac. "A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment." Psychopharmacology 233, br. 17 (2016): 3259-3267. https://doi.org/10.1007/s00213-016-4364-0

Šagud, M., et al. (2016) 'A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment', Psychopharmacology, 233(17), str. 3259-3267. doi: 10.1007/s00213-016-4364-0

Šagud M, Nikolac Perković M, Vuksan Ćusa B, Maravić A, Švob Štrac D, Mihaljević Peleš A, i sur.. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology [Internet]. 09.2016. [pristupljeno 01.05.2024.];233(17):3259-3267. doi: 10.1007/s00213-016-4364-0

M. Šagud, et al., "A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment", Psychopharmacology, vol. 233, br. 17, str. 3259-3267, Rujan 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:274898. [Citirano: 01.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:274898
Podaci o radu
Naslov (engleski)A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment
AutorMarina Šagud
AutorMatea Nikolac Perković
AutorBjanka Vuksan-Ćusa
AutorAnja Maravić
AutorDubravka Švob Štrac
AutorAlma Mihaljević Peleš
AutorMaja Živković
AutorZorana Kušević
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Various antidepressants occupy brain serotonin transporter (SERT), decrease platelet serotonin (5-HT) concentration, and normalize reduced plasma brain-derived neurotrophic factor (BDNF) concentrations in depressed patients. Vortioxetine is a recently introduced antidepressant with a multimodal mechanism of action. In addition to SERT inhibition, vortioxetine acts via different 5-HT receptors. To further elucidate its mechanism of action, we have investigated the effects of vortioxetine on platelet 5-HT and plasma BDNF concentrations in patients with major depression. ----- METHODS: Platelet 5-HT and plasma BDNF concentrations were determined in 44 healthy subjects at baseline and in 44 depressed patients before and after 4 weeks of treatment with vortioxetine (5-15 mg daily). Platelet 5-HT concentration was determined using the ortho-phthalaldehyde-enhanced fluorometric method, and plasma BDNF concentration using a commercial enzyme-linked immunosorbent assay (Quantikine ELISA, R&D Systems). ----- RESULTS: At baseline, platelet 5-HT concentrations did not differ between depressed and control subjects, but plasma BDNF values were lower (p = 0.011; ω = 0.80) in depressed patients than in healthy subjects. Vortioxetine treatment significantly (p < 0.0001; ω = 0.80) decreased platelet 5-HT concentration and significantly (p = 0.004; ω = 0.80) increased plasma BDNF concentration in depressed patients compared to their baseline values. Age, gender, and smoking were not significantly associated with platelet 5-HT and plasma BDNF concentrations. ----- CONCLUSION: Despite a novel mechanism of action, vortioxetine shares some common effects with other antidepressants. This study is the first to show that, in addition to clinical improvement, 4 weeks of treatment with vortioxetine (5-15 mg daily), decreased platelet 5-HT and increased plasma BDNF concentrations in depressed patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPsychopharmacology
Brojčani podacivol. 233, br. 17, str. 3259-3267
p-ISSN0033-3158
DOIhttps://doi.org/10.1007/s00213-016-4364-0
URN:NBNurn:nbn:hr:105:274898
Datum objave publikacije2016-09
URL dokumentahttp://doi.org/10.1007/s00213-016-4364-0
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:01:10