prikaz prve stranice dokumenta Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival
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Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival
International Journal of Oral and Maxillofacial Surgery, 44 (2015), 9; 1075-1080. https://doi.org/10.1016/j.ijom.2015.05.009
Lukšić, Ivica; Suton, Petar; Manojlović, Spomenka; Virag, Mišo; Petrovečki, Mladen; Macan, Darko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Lukšić, I., Suton, P., Manojlović, S., Virag, M., Petrovečki, M. i Macan, D. (2015). Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival. International Journal of Oral and Maxillofacial Surgery, 44. (9), 1075-1080. doi: 10.1016/j.ijom.2015.05.009

Lukšić, Ivica, et al. "Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival." International Journal of Oral and Maxillofacial Surgery, vol. 44, br. 9, 2015, str. 1075-1080. https://doi.org/10.1016/j.ijom.2015.05.009

Lukšić, Ivica, Petar Suton, Spomenka Manojlović, Mišo Virag, Mladen Petrovečki i Darko Macan. "Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival." International Journal of Oral and Maxillofacial Surgery 44, br. 9 (2015): 1075-1080. https://doi.org/10.1016/j.ijom.2015.05.009

Lukšić, I., et al. (2015) 'Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival', International Journal of Oral and Maxillofacial Surgery, 44(9), str. 1075-1080. doi: 10.1016/j.ijom.2015.05.009

Lukšić I, Suton P, Manojlović S, Virag M, Petrovečki M, Macan D. Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival. International Journal of Oral and Maxillofacial Surgery [Internet]. 09.2015. [pristupljeno 09.11.2024.];44(9):1075-1080. doi: 10.1016/j.ijom.2015.05.009

I. Lukšić, P. Suton, S. Manojlović, M. Virag, M. Petrovečki i D. Macan, "Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival", International Journal of Oral and Maxillofacial Surgery, vol. 44, br. 9, str. 1075-1080, Rujan 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:029855. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:029855
Podaci o radu
Naslov (engleski)Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival
AutorIvica Lukšić
AutorPetar Suton
AutorSpomenka Manojlović
AutorMišo Virag
AutorMladen Petrovečki
AutorDarko Macan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The aim of the present study was to assess the frequency of appearance of stromal myofibroblasts in patients with oral squamous cell carcinoma (OSCC) and to further clarify whether myofibroblasts influence tumour suppression or progression. Surgical resection specimens from 152 patients with cT1-T3N0 OSCC were analysed. The frequency of myofibroblasts within the tumour stroma was assessed immunohistochemically and compared with other clinical and histopathological factors. The immunohistochemical reaction for alpha-smooth muscle actin showed positive cells in the stroma of 84.2% of OSCC (n=128). An increased presence of myofibroblasts in the tumour stroma was significantly correlated with T stage (P=0.019), the presence of occult neck metastasis (P<0.001), regional recurrence (P=0.037), and distant metastasis (P=0.008). There was also an association between the presence of myofibroblasts and patient survival (P=0.009). The presence of myofibroblasts was not associated with local recurrence, tumour cell differentiation, mode of invasion, or bone invasion. The results of this study suggest that myofibroblast proliferation facilitates tumour invasion, the occurrence of occult neck disease, and distant metastasis. The survival rate was poorer in patients with abundant myofibroblasts. Further investigations on tumour-associated stroma at the invasive front are needed in order to establish new diagnostic markers and therapeutic strategies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Journal of Oral and Maxillofacial Surgery
Brojčani podacivol. 44, br. 9, str. 1075-1080
p-ISSN0901-5027
DOIhttps://doi.org/10.1016/j.ijom.2015.05.009
URN:NBNurn:nbn:hr:105:029855
Datum objave publikacije2015-09
URL dokumentahttps://doi.org/10.1016/j.ijom.2015.05.009
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:03:20