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Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis
Clinical Rheumatology, 26 (2007), 8; 1332-1334. https://doi.org/10.1007/s10067-006-0474-0
Jelušić, Marija; Lukić, Ivan Krešimir; Tambić-Bukovac, Lana; Dubravčić, Klara; Malčić, Ivan; Rudan, Igor; Batinić, Drago

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Jelušić, M., Lukić, I. K., Tambić Bukovac, L., Dubravčić, K., Malčić, I., Rudan, I. i Batinić, D. (2007). Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis. Clinical Rheumatology, 26. (8), 1332-1334. doi: 10.1007/s10067-006-0474-0

Jelušić, Marija, et al. "Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis." Clinical Rheumatology, vol. 26, br. 8, 2007, str. 1332-1334. https://doi.org/10.1007/s10067-006-0474-0

Jelušić, Marija, Ivan Krešimir Lukić, Lana Tambić Bukovac, Klara Dubravčić, Ivan Malčić, Igor Rudan i Drago Batinić. "Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis." Clinical Rheumatology 26, br. 8 (2007): 1332-1334. https://doi.org/10.1007/s10067-006-0474-0

Jelušić, M., et al. (2007) 'Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis', Clinical Rheumatology, 26(8), str. 1332-1334. doi: 10.1007/s10067-006-0474-0

Jelušić M, Lukić IK, Tambić Bukovac L, Dubravčić K, Malčić I, Rudan I, i sur.. Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis. Clinical Rheumatology [Internet]. 08.2007. [pristupljeno 26.11.2024.];26(8):1332-1334. doi: 10.1007/s10067-006-0474-0

M. Jelušić, et al., "Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis", Clinical Rheumatology, vol. 26, br. 8, str. 1332-1334, Kolovoz 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:779566. [Citirano: 26.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:779566
Podaci o radu
Naslov (engleski)Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis
AutorMarija Jelušić
AutorIvan Krešimir Lukić
AutorLana Tambić-Bukovac
AutorKlara Dubravčić
AutorIvan Malčić
AutorIgor Rudan
AutorDrago Batinić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The objective of this report is to explore the balance between serum and synovial fluid levels of interleukin (IL)-18 in children with juvenile idiopathic arthritis (JIA). Blood samples were obtained from 81 children with JIA and 18 control children. Synovial fluid samples were collected from 16 children with oligoarticular JIA. Concentrations of IL-18 were determined using commercial kit. Patients with systemic JIA had higher serum levels of IL-18 than patients with other forms of JIA or control children, both during the active (median, range: 6,240, 1,600–78,750 pg/ml) and inactive (1,615, 513–3,270 pg/ml) phase of disease [analysis of variance (ANOVA), P < 0.05). Levels of IL-18 in sera of children with oligoarticular JIA (255, 89–4,342 pg/ml) were similar to the respective synovial fluid levels (217, 89–1,245 pg/ml). Serum levels of IL-18 were proportional to the erythrocyte sedimentation rate and levels of C-reactive protein, but inversely proportional to the haemoglobin levels. IL-18 appears to be an important mediator of systemic JIA, while it seems of a lesser relevance in pathogenesis of other JIA forms. Therefore, inhibition of IL-18 might be a base for a successful biological therapy for systemic JIA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaClinical Rheumatology
Brojčani podacivol. 26, br. 8, str. 1332-1334
p-ISSN0770-3198
DOIhttps://doi.org/10.1007/s10067-006-0474-0
URN:NBNurn:nbn:hr:105:779566
Datum objave publikacije2007-08
URL dokumentahttps://doi.org/10.1007/s10067-006-0474-0
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:25:47