Despite decreased incidency of stomach cancer in last few decades, it still occupies high, fifth place by frequency and third by mortality between all cancers in the world, and more than 700 000 people with diagnosed stomach cancer die every year. Although stomach cancer is still the type of cancer mostly diagnosed in older population, the part of young population with this disease can not be ignored. Etiology of stomach cancer is still unknown, but, multifactorial causality is considered as a key for developing this malignant disease. Genetic predisposition is surely relevant, yet, unproper nutrition and non-balanced lifestyle are considered as probably one of the most important risk factors for this disease. Also, there is evidenced etiopathogenic relation between infection with bacillus Helicobacter pylori and development of stomach cancer. Clinical symptoms of stomach cancer are various, and depend about the stadium of disease, but, although there are many signs and symptoms connected with it, most of them are - unspecific. It is also one of the main reasons why the cancer is mostly recognized in later stadium, when it has already spread around. The main treatment for stomach cancer is surgery. Different subtypes of stomach cancer are presented with different morphological characteristics and clinical symptoms, and, according to that, require different access in surgical treatment.