prikaz prve stranice dokumenta Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients
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Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients
International Journal of Cardiology, 261 (2018); 109-113. https://doi.org/doi:10.1016/j.ijcard.2018.03.037
Potočnjak, Ines; Radulović, Bojana; Degoricija, Vesna; Trbušić, Matias; Pregartner, Gudrun; Berghold, Andrea; Meinitzer, Andreas; Frank, Saša

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Potočnjak, I., Radulović, B., Degoricija, V., Trbušić, M., Pregartner, G., Berghold, A. ... Frank, S. (2018). Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients. International Journal of Cardiology, 261., 109-113. doi: doi:10.1016/j.ijcard.2018.03.037

Potočnjak, Ines, et al. "Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients." International Journal of Cardiology, vol. 261, 2018, str. 109-113. https://doi.org/doi:10.1016/j.ijcard.2018.03.037

Potočnjak, Ines, Bojana Radulović, Vesna Degoricija, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Andreas Meinitzer i Saša Frank. "Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients." International Journal of Cardiology 261 (2018): 109-113. https://doi.org/doi:10.1016/j.ijcard.2018.03.037

Potočnjak, I., et al. (2018) 'Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients', International Journal of Cardiology, 261, str. 109-113. doi: doi:10.1016/j.ijcard.2018.03.037

Potočnjak I, Radulović B, Degoricija V, Trbušić M, Pregartner G, Berghold A, i sur.. Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients. International Journal of Cardiology [Internet]. 15.06.2018. [pristupljeno 24.12.2024.];261:109-113. doi: doi:10.1016/j.ijcard.2018.03.037

I. Potočnjak, et al., "Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients", International Journal of Cardiology, vol. 261, str. 109-113, Lipanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:706387. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:706387
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Naslov (engleski)Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients
AutorInes Potočnjak
AutorBojana Radulović
AutorVesna Degoricija
AutorMatias Trbušić
AutorGudrun Pregartner
AutorAndrea Berghold
AutorAndreas Meinitzer
AutorSaša Frank
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine are established predictors of total and cardiovascular mortality. However, the predictive capacity of ADMA and SDMA for hospital and 3-months mortality of patients with acute heart failure (AHF) is unknown. ----- METHODS & RESULTS: Out of 152 included AHF patients, 79 (52%) were female, and the mean patient age was 75.2 ± 10.3 years. Hospital and three-month mortality rates were 14.5% and 27.4%, respectively. Serum ADMA and SDMA levels at admission, determined by reversed phase high performance liquid chromatography, were higher in patients having at least one of the three signs implying venous volume overload (enlarged liver, ascites, peripheral edema), a consequence of right-sided heart failure, compared to patients without those signs. Univariable logistic regression analyses revealed a significant positive association of ADMA and SDMA concentrations with hospital mortality [odds ratio (OR) and 95% confidence interval (CI) per standard deviation (SD) increase: 2.22 (1.37-3.79), p = 0.002, and 2.04 (1.34-3.18), p = 0.001, respectively], and 3-months mortality [2.06 (1.36-3.26), p = 0.001, and 2.52 (1.67-4.04), p < 0.001, respectively]. These associations remained significant after adjusting for age, sex, mean arterial pressure, low-density lipoprotein cholesterol, glomerular filtration rate, and N-terminal pro-brain natriuretic peptide. ----- CONCLUSIONS: We conclude that ADMA and SDMA concentrations are associated with hospital and 3-month mortality and are increased by venous volume overload in AHF patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Cardiology
Brojčani podacivol. 261, str. 109-113
p-ISSN0167-5273
DOIhttps://doi.org/doi:10.1016/j.ijcard.2018.03.037
URN:NBNurn:nbn:hr:105:706387
Datum objave publikacije2018-06-15
URL dokumentahttp://doi.org/10.1016/j.ijcard.2018.03.037
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:08:47