prikaz prve stranice dokumenta Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients
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Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients
Collegium Antropologicum, 31 (2007), 4; 1065-1070. urn:nbn:hr:105:937625
Peršec, Jasminka; Buković, Damir; Majerić-Kogler, Višnja; Šakić, Katarina; Peršec, Zoran; Kasum, Miro

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Peršec, J., Buković, D., Majerić Kogler, V., Šakić, K., Peršec, Z. i Kasum, M. (2007). Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients. Collegium Antropologicum, 31. (4), 1065-1070. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:937625

Peršec, Jasminka, et al. "Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients." Collegium Antropologicum, vol. 31, br. 4, 2007, str. 1065-1070. https://urn.nsk.hr/urn:nbn:hr:105:937625

Peršec, Jasminka, Damir Buković, Višnja Majerić Kogler, Katarina Šakić, Zoran Peršec i Miro Kasum. "Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients." Collegium Antropologicum 31, br. 4 (2007): 1065-1070. https://urn.nsk.hr/urn:nbn:hr:105:937625

Peršec, J., et al. (2007) 'Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients', Collegium Antropologicum, 31(4), str. 1065-1070. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:937625 (Datum pristupa: 30.11.2024.)

Peršec J, Buković D, Majerić Kogler V, Šakić K, Peršec Z, Kasum M. Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients. Collegium Antropologicum [Internet]. 12.2007. [pristupljeno 30.11.2024.];31(4):1065-1070. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:937625

J. Peršec, D. Buković, V. Majerić Kogler, K. Šakić, Z. Peršec i M. Kasum, "Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients", Collegium Antropologicum, vol. 31, br. 4, str. 1065-1070, Prosinac 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:937625. [Citirano: 30.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:937625
Podaci o radu
Naslov (engleski)Analysis of preincisional and postincisional treatment with alpha2-adrenoreceptor agonist clonidine regarding analgesic consumption and hemodynamic stability in surgical patients
AutorJasminka Peršec
AutorDamir Buković
AutorVišnja Majerić-Kogler
AutorKatarina Šakić
AutorZoran Peršec
AutorMiro Kasum
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Preemptive analgesia aims to prevent the sensitization of central nervous system, hence the development of pathologic pain after tissular injury. The aim of the study was to assess the effect of preincisional clonidine treatment on analgesic consumption and hemodynamic stability compared to clonidine administered at the end of the operation and control group. Ninety-one patients undergoing elective colorectal surgery were randomly assigned to four groups: peroral clonidine before operation, epidural clonidine before operation, epidural clonidine at the end of operation, and epidural saline before operation as a control group. After the operation, patient-controlled analgesia with epidural morphine was instituted. Analgesic consumption, blood pressure and heart rate were obtained at 1, 2, 6 and 24 h postoperatively, and the cumulative consumption of analgesics was assessed at the end of the study period. Significant differences (p < 0.05) in postoperative systolic blood pressure, with highest hemodynamic stability was observed at 1 h and 6 h in the group of patients administered epidural clonidine before operation. In this group of patients we found significant reduction in analgesic consumption during the study period (p < 0.05), compared to other groups. The cumulative consumption of analgesics assessed at the end of the study period was significantly reduced (p < 0.05) in the group of patients administered epidural clonidine before operation (8.40 +/- 3.74, respectively) as compared with the peroral clonidine before operation (16.79 +/- 5.75, respectively), epidural clonidine at the end of the operation (11.11 +/- 4.24, respectively) and control group of patients (18.00 +/- 6.45, respectively). Preincisional administration of epidural clonidine was associated with a significantly lower analgesic use, lower cumulative analgesic consumption and greater hemodynamic stability, in comparison with other groups.
Sažetak (hrvatski)
Osnova preemptivne analgezije je sprječavanje nastanka senzitizacije središnjeg živčanog sustava i posljedičnog razvoja patološke boli uslijed tkivne ozljede. Cilj ove studije bila je usporedba učinka prijeoperacijske primjene klonidina na potrošnju analgetika i hemodinamsku stabilnost bolesnika u odnosu na primjenu klonidina na kraju operacije i kontrolnu skupinu. Uzorak od ukupno 91 bolesnika, predviđenih za operacijski zahvat u kolorektalnoj kirurgiji, metodom randomizacije podijeljen je u četiri skupine: klonidin per os prije operacije, epiduralni klonidin prije operacije, epiduralni klonidin na kraju operacije i kontrolna skupina. Nakon operacijskog zahvata, na pojavu osjeta boli svi ispitanici su primili analgetik morfin. Parametri krvnog tlaka, pulsa i učestalosti potrošnje analgetika proučavani su u vremenskom slijedu 1., 2., 6. i 24. sata od operacijskog zahvata, a ukupna potrošnja analgetika na završetku ispitivanja. Značajne razlike (p<0,05) u vrijednostima sistoličkog krvnog tlaka, uz najveću hemodinamsku stabilnost bolesnika dokazane su u skupini s klonidinom primjenjenim epiduralno prije operacije u 1. i 6. satu ispitivanja. U toj skupini bolesnika nađeno je značajno smanjenje primjene analgetika tijekom ispitivanja (p<0,05), u usporedbi s ostalim skupinama. Ukupna potrošnja analgetika na završetku ispitivanja bila je značajno manja (p<0,05) u skupini bolesnika s klonidinom primjenjenim epiduralno prije operacije (8,40±3,74), u usporedbi s klonidinom primjenjenim per os prije operacije (16,79±5,75), klonidinom epiduralno na kraju operacije (11,11±4,24) i kontrolnom skupinom bolesnika (18,00±6,45). Zaključujemo da je prijeoperacijska epiduralna primjena klonidina povezana s smanjenom učestalosti primjene analgetika, smanjenom ukupnom potrošnjom analgetika i većom hemodinamskom stabilnosti, u usporedbi s ostalim ispitivanim skupinama.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium Antropologicum
Brojčani podacivol. 31, br. 4, str. 1065-1070
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:937625
Datum objave publikacije2007-12
URL dokumentahttps://hrcak.srce.hr/26947
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:52:20