prikaz prve stranice dokumenta The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects
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The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects
Neuroscience Letters, 462 (2009), 1; 45-48. https://doi.org/10.1016/j.neulet.2009.06.080
Pivac, Nela; Nedić, Gordana; Mustapić, Maja; Babić, Ana; Stipčević, Tamara; Borovečki, Fran; Hajnšek, Sanja; Mück-Šeler, Dorotea

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Pivac, N., Nedić, G., Mustapić, M., Babić, A., Stipčević, T., Borovečki, F. ... Mück Šeler, D. (2009). The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects. Neuroscience Letters, 462. (1), 45-48. doi: 10.1016/j.neulet.2009.06.080

Pivac, Nela, et al. "The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects." Neuroscience Letters, vol. 462, br. 1, 2009, str. 45-48. https://doi.org/10.1016/j.neulet.2009.06.080

Pivac, Nela, Gordana Nedić, Maja Mustapić, Ana Babić, Tamara Stipčević, Fran Borovečki, Sanja Hajnšek i Dorotea Mück Šeler. "The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects." Neuroscience Letters 462, br. 1 (2009): 45-48. https://doi.org/10.1016/j.neulet.2009.06.080

Pivac, N., et al. (2009) 'The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects', Neuroscience Letters, 462(1), str. 45-48. doi: 10.1016/j.neulet.2009.06.080

Pivac N, Nedić G, Mustapić M, Babić A, Stipčević T, Borovečki F, i sur.. The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects. Neuroscience Letters [Internet]. 02.10.2009. [pristupljeno 28.04.2024.];462(1):45-48. doi: 10.1016/j.neulet.2009.06.080

N. Pivac, et al., "The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects", Neuroscience Letters, vol. 462, br. 1, str. 45-48, Listopad 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:336456. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:336456
Podaci o radu
Naslov (engleski)The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects
AutorNela Pivac
AutorGordana Nedić
AutorMaja Mustapić
AutorAna Babić
AutorTamara Stipčević
AutorFran Borovečki
AutorSanja Hajnšek
AutorDorotea Mück-Šeler
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
A polymorphism in the serotonin transporter gene (5-HTTLPR) is frequently studied for association with antidepressant treatment response, different personality traits, and psychiatric disorders. Baseline platelet serotonin (5-HT) concentration has been proposed to indicate a good or a poor treatment response to antidepressant drugs and to be associated with particular symptoms in psychiatric disorders. The aim of the study was to elucidate the genotype-phenotype relationship between platelet 5-HT concentration and 5-HTTLPR in healthy subjects. The frequency of 5-HTTLPR genotypes and alleles, as well as platelet 5-HT concentration was evaluated in 434 male and 86 female unrelated healthy medication-free Caucasian subjects of Croatian origin. A two-way ANOVA revealed no significant difference in platelet 5-HT concentration subdivided according to the particular 5-HTTLPR genotype, no significant effect of sex, no significant effect of genotype, and no significant interaction between sex and genotype on platelet 5-HT concentration. In addition, one-way ANOVA did not detect significant effects of homozygous S/S genotype, or homozygous L/L genotype on platelet 5-HT concentration. Our results showed a lack of significant association between platelet 5-HT concentration and 5-HTTLPR variants, suggesting that there is no functional relationship between 5-HTTLPR alleles and platelet 5-HT concentration in the large groups of healthy male and female medication-free Caucasian subjects, free of neuro-psychiatric disorders.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeuroscience Letters
Brojčani podacivol. 462, br. 1, str. 45-48
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2009.06.080
URN:NBNurn:nbn:hr:105:336456
Datum objave publikacije2009-10-02
URL dokumentahttps://doi.org/10.1016/j.neulet.2009.06.080
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:26:34