prikaz prve stranice dokumenta Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors
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Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors
Pathology, Research and Practice, 206 (2010), 3; 163-167. https://doi.org/10.1016/j.prp.2009.10.007
Vladušić, Tomislav; Hrašćan, Reno; Vrhovac, Ivana; Krušlin, Božo; Gamulin, Marija; Grgić, Mislav; Pećina-Šlaus, Nives; Franekić Čolić, Jasna

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Vladušić, T., Hrašćan, R., Vrhovac, I., Krušlin, B., Gamulin, M., Grgić, M. ... Franekić Čolić, J. (2010). Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. Pathology, Research and Practice, 206. (3), 163-167. doi: 10.1016/j.prp.2009.10.007

Vladušić, Tomislav, et al. "Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors." Pathology, Research and Practice, vol. 206, br. 3, 2010, str. 163-167. https://doi.org/10.1016/j.prp.2009.10.007

Vladušić, Tomislav, Reno Hrašćan, Ivana Vrhovac, Božo Krušlin, Marija Gamulin, Mislav Grgić, Nives Pećina Šlaus i Jasna Franekić Čolić. "Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors." Pathology, Research and Practice 206, br. 3 (2010): 163-167. https://doi.org/10.1016/j.prp.2009.10.007

Vladušić, T., et al. (2010) 'Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors', Pathology, Research and Practice, 206(3), str. 163-167. doi: 10.1016/j.prp.2009.10.007

Vladušić T, Hrašćan R, Vrhovac I, Krušlin B, Gamulin M, Grgić M, i sur.. Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. Pathology, Research and Practice [Internet]. 15.03.2010. [pristupljeno 22.11.2024.];206(3):163-167. doi: 10.1016/j.prp.2009.10.007

T. Vladušić, et al., "Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors", Pathology, Research and Practice, vol. 206, br. 3, str. 163-167, Ožujak 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:156165. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:156165
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Naslov (engleski)Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors
AutorTomislav Vladušić
AutorReno Hrašćan
AutorIvana Vrhovac
AutorBožo Krušlin
AutorMarija Gamulin
AutorMislav Grgić
AutorNives Pećina-Šlaus
AutorJasna Franekić Čolić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human testicular germ cell tumors (TGCTs) are histologically heterogenous neoplasms with a variable malignant potential. Two main groups of germ cell tumors occur in men: seminomas and nonseminomas. In the present study, a set of four tumor suppressor genes was investigated in testicular cancers. CDH1, APC, p53, and nm23-H1 genes were tested for loss of heterozygosity (LOH). Thirty-eight testicular germ cell tumors (17 seminomas and 21 nonseminomas) were analyzed by PCR using restriction fragment length polymorphism or the dinucleotide/tetranucleotide repeat polymorphism method. An allelic loss of p53 at exon 4 was detected in five nonseminomas, whereas LOH of p53 at intron 6 occurred in one of the seminoma and two of the nonseminoma samples. Allelic losses of the APC gene were present in three seminomas and one nonseminoma, whereas one seminoma and three nonseminomas showed LOH of CDH1. The analysis of allelic losses showed no common structural genetic alterations in tumor tissues, although a different pattern of LOH was observed between the two main histological groups of TGCTs.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPathology, Research and Practice
Brojčani podacivol. 206, br. 3, str. 163-167
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2009.10.007
URN:NBNurn:nbn:hr:105:156165
Datum objave publikacije2010-03-15
URL dokumentahttps://doi.org/10.1016/j.prp.2009.10.007
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:29:19