prikaz prve stranice dokumenta Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection
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Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection
European Journal of Pharmacology, 633 (2010), 1-3; 10-14. https://doi.org/10.1016/j.ejphar.2010.01.020
Bach-Rojecky, Lidija; Šalković-Petrišić, Melita; Lacković, Zdravko

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Bach Rojecky, L., Šalković Petrišić, M. i Lacković, Z. (2010). Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection. European Journal of Pharmacology, 633. (1-3), 10-14. doi: 10.1016/j.ejphar.2010.01.020

Bach Rojecky, Lidija, et al. "Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection." European Journal of Pharmacology, vol. 633, br. 1-3, 2010, str. 10-14. https://doi.org/10.1016/j.ejphar.2010.01.020

Bach Rojecky, Lidija, Melita Šalković Petrišić i Zdravko Lacković. "Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection." European Journal of Pharmacology 633, br. 1-3 (2010): 10-14. https://doi.org/10.1016/j.ejphar.2010.01.020

Bach Rojecky, L., Šalković Petrišić, M. i Lacković, Z. (2010) 'Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection', European Journal of Pharmacology, 633(1-3), str. 10-14. doi: 10.1016/j.ejphar.2010.01.020

Bach Rojecky L, Šalković Petrišić M, Lacković Z. Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection. European Journal of Pharmacology [Internet]. 10.05.2010. [pristupljeno 15.05.2024.];633(1-3):10-14. doi: 10.1016/j.ejphar.2010.01.020

L. Bach Rojecky, M. Šalković Petrišić i Z. Lacković, "Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection", European Journal of Pharmacology, vol. 633, br. 1-3, str. 10-14, Svibanj 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:481823. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:481823
Podaci o radu
Naslov (engleski)Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection
AutorLidija Bach-Rojecky
AutorMelita Šalković-Petrišić
AutorZdravko Lacković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We investigated antinociceptive activity of botulinum toxin type A (BTX-A) in a model of diabetic neuropathic pain in rats. Male Wistar rats were made diabetic by a single intraperitoneal injection of streptozotocin (80mg/kg). Sensitivity to mechanical and thermal stimuli was measured with the paw-pressure and hot-plate test, respectively. The formalin test was used to measure sensitivity to chemical stimuli. Diabetic animals with pain thresholds lower for at least 25% compared to the non-diabetic group were considered neuropathic and were injected with BTX-A either subcutaneously (3, 5 and 7U/kg) or intrathecally (1U/kg). Mechanical and thermal sensitivity was measured at several time-points. After peripheral application, BTX-A (5 and 7U/kg) reduced mechanical and thermal hypersensitivity not only on ipsilateral, but on contralateral side, too. The antinociceptive effect started 5days following BTX-A injection and lasted at least 15days. Formalin-induced hypersensitivity in diabetic animals was abolished as well. When applied intrathecally, BTX-A (1U/kg) reduced diabetic hyperalgesia within 24h supporting the assumption of retrograde axonal transport of BTX-A from the peripheral site of injection to central nervous system. The results presented here demonstrate the long-lasting pain reduction after single BTX-A injection in the animals with diabetic neuropathy. The bilateral pain reduction after unilateral toxin application and the effectiveness of lower dose with the faster onset after the intrathecal injection suggest the involvement of the central nervous system in the antinociceptive action of BTX-A in painful diabetic neuropathy.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEuropean Journal of Pharmacology
Brojčani podacivol. 633, br. 1-3, str. 10-14
p-ISSN0014-2999
DOIhttps://doi.org/10.1016/j.ejphar.2010.01.020
URN:NBNurn:nbn:hr:105:481823
Datum objave publikacije2010-05-10
URL dokumentahttps://doi.org/10.1016/j.ejphar.2010.01.020
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:29:38