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Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects
Neuroscience Letters, 473 (2010), 3; 216-219. https://doi.org/10.1016/j.neulet.2010.02.050
Nedić, Gordana; Matea Nikolac, Matea; Borovečki, Fran; Hajnšek, Sanja; Muck-Šeler, Dorotea; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Nedić, G., Matea Nikolac, M., Borovečki, F., Hajnšek, S., Muck Šeler, D. i Pivac, N. (2010). Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neuroscience Letters, 473. (3), 216-219. doi: 10.1016/j.neulet.2010.02.050

Nedić, Gordana, et al. "Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects." Neuroscience Letters, vol. 473, br. 3, 2010, str. 216-219. https://doi.org/10.1016/j.neulet.2010.02.050

Nedić, Gordana, Matea Matea Nikolac, Fran Borovečki, Sanja Hajnšek, Dorotea Muck Šeler i Nela Pivac. "Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects." Neuroscience Letters 473, br. 3 (2010): 216-219. https://doi.org/10.1016/j.neulet.2010.02.050

Nedić, G., et al. (2010) 'Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects', Neuroscience Letters, 473(3), str. 216-219. doi: 10.1016/j.neulet.2010.02.050

Nedić G, Matea Nikolac M, Borovečki F, Hajnšek S, Muck Šeler D, Pivac N. Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neuroscience Letters [Internet]. 12.04.2010. [pristupljeno 05.11.2024.];473(3):216-219. doi: 10.1016/j.neulet.2010.02.050

G. Nedić, M. Matea Nikolac, F. Borovečki, S. Hajnšek, D. Muck Šeler i N. Pivac, "Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects", Neuroscience Letters, vol. 473, br. 3, str. 216-219, Travanj 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:782475. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:782475
Podaci o radu
Naslov (engleski)Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects
AutorGordana Nedić
AutorMatea Matea Nikolac
AutorFran Borovečki
AutorSanja Hajnšek
AutorDorotea Muck-Šeler
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Tobacco smoking is a global health problem. The association of a functional common polymorphism in the catechol-o-methyltransferase gene (COMT Val158Met) with smoking behavior has been extensively studied, but with divergent findings. In the present study the frequency of COMT genotypes and alleles was evaluated in 578 male and a smaller group of 79 female unrelated, medication-free Caucasian healthy subjects of Croatian origin. Smokers were classified as subjects smoking </=10 cigarettes per day, while subjects who never smoked in their life were regarded as nonsmokers. A chi(2)-test with standardized residuals and Bonferroni correction revealed significant (P=0.017) differences in Met/Met, Met/Val or Val/Val genotype frequency between male smokers and nonsmokers. This significant association between COMT Val158Met polymorphism and smoking was not detected in female subjects, due to the small number of women, which represents a limitation of the study. Our results confirmed the significant association between COMT variants and smoking, which was due to the higher frequency of Val/Val homozygotes in male smokers compared to male nonsmokers. These results suggest that carriers of the high activity COMT variant are more prone to develop a higher level of nicotine dependence, or that they release more dopamine than carriers of Met/Met or Met/Val genotypes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaNeuroscience Letters
Brojčani podacivol. 473, br. 3, str. 216-219
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2010.02.050
URN:NBNurn:nbn:hr:105:782475
Datum objave publikacije2010-04-12
URL dokumentahttps://doi.org/10.1016/j.neulet.2010.02.050
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:35:33