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Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35 (2011), 2; 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019
Borovečki, Fran; Klepac, Nataša; Muck-Šeler, Dorotea; Hajnšek, Sanja; Mubrin, Zdenko; Pivac, Nela

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Borovečki, F., Klepac, N., Muck Šeler, D., Hajnšek, S., Mubrin, Z. i Pivac, N. (2011). Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35. (2), 340-347. doi: 10.1016/j.pnpbp.2010.12.019

Borovečki, Fran, et al. "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics." Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 35, br. 2, 2011, str. 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019

Borovečki, Fran, Nataša Klepac, Dorotea Muck Šeler, Sanja Hajnšek, Zdenko Mubrin i Nela Pivac. "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics." Progress in Neuro-Psychopharmacology & Biological Psychiatry 35, br. 2 (2011): 340-347. https://doi.org/10.1016/j.pnpbp.2010.12.019

Borovečki, F., et al. (2011) 'Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(2), str. 340-347. doi: 10.1016/j.pnpbp.2010.12.019

Borovečki F, Klepac N, Muck Šeler D, Hajnšek S, Mubrin Z, Pivac N. Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics. Progress in Neuro-Psychopharmacology & Biological Psychiatry [Internet]. 30.03.2011. [pristupljeno 22.11.2024.];35(2):340-347. doi: 10.1016/j.pnpbp.2010.12.019

F. Borovečki, N. Klepac, D. Muck Šeler, S. Hajnšek, Z. Mubrin i N. Pivac, "Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics", Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 35, br. 2, str. 340-347, Ožujak 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:983485. [Citirano: 22.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:983485
Podaci o radu
Naslov (engleski)Unraveling the biological mechanisms in Alzheimer's disease - lessons from genomics
AutorFran Borovečki
AutorNataša Klepac
AutorDorotea Muck-Šeler
AutorSanja Hajnšek
AutorZdenko Mubrin
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Alzheimer's disease (AD) is the most common form of dementia and the most common neurodegenerative disease, with a complex genetic background. Genome-wide association studies (GWAS) have yielded important new insights into genetic mechanisms of AD pathology. Current results unequivocally confirm apolipoprotein E (APOE) as a major genetic risk factor for development of late onset AD. Additional associations of more than twenty genes have also been identified and replicated in subsequent genetic studies. Despite the exciting new GWAS data which have emerged in the last few years, it has become clear that common variants within the genome cannot fully explain the underlying genetic risk for AD. Novel approaches such as genome-wide analysis of copy number variations (CNV) or low-frequency rare functional gene variants may provide additional insight into genetic basis of AD. In this review we summarize the findings of eighteen GWAS studies in AD performed to date, with an emphasis on potential future developments in the quest for genetic risk factors of AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProgress in Neuro-Psychopharmacology & Biological Psychiatry
Brojčani podacivol. 35, br. 2, str. 340-347
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2010.12.019
URN:NBNurn:nbn:hr:105:983485
Datum objave publikacije2011-03-30
URL dokumentahttps://doi.org/10.1016/j.pnpbp.2010.12.019
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 12:02:13