Title of work: Occurrence of pneumonia associated with mechanical ventilation before and after oral hygiene intervention in the intensive care unit Introduction and objective: The topic of the research that will be conducted is related to the occurrence of pneumonia associated with mechanical ventilation in patients who underwent a new oral hygiene intervention in such patients. The aim of the work is to prove that proper implementation of oral hygiene reduces the occurrence of VAP in endotracheally intubated and mechanically ventilated patients. The research also aims to prove that the new protocol is "better", and the results of the research will contribute to the introduction of the new protocol into the standard clinical practice of the department and clinic. Subjects and methods: From the research, it is expected that from the patients (N=20) who are divided into two groups: control (where the old protocol is applied) and intervention (where the new protocol is applied), those from the intervention group will have a reduced incidence occurrences of VAP and mortality, and that their number of days on mechanical ventilation will be lower compared to the control group. The measuring instrument in the research will be a set of data about the patient, therapy, diagnosis, findings, etc. The data will be processed in one of the computer programs for statistical data processing. The measuring instrument in the research will be a set of data about the patient, therapy, diagnosis, findings, etc. New oral hygiene implementation protocols will be defined and evaluated by analyzing tracheal aspirates on three occasions. Results: The research is expected to give favorable results in the form of improved prevention and care strategies for the axial cavity of the patient in the intensive care unit, and as a result, the introduction of a new guideline into the standard practice of the ward and hospital is expected. It is expected that the research hypothesis will be accepted. Conclusion: Patients from the intervention group had a reduced occurrence of VAP, shortened time spent on mechanical ventilation and time spent in the ICU, which contributed to their faster and better recovery and reduced workload in the intensive care unit and treatment costs.