Total hip replacement is a common procedure in orthopedics that removes damaged bone and cartilage and replaces it with prosthetic components. Total hip arthroplasty performed by an experienced surgical team gives very effective results, providing pain relief, functional restoration and improved quality of life, but one should be aware of the possible complications of the procedure. One of the frequent complications after the installation of a total hip endoprosthesis is infection. To successfully treat the underlying infection while preserving joint function, treatment must include effective diagnosis and patient-tailored treatment based on an algorithm and interdisciplinary collaboration. Clinical, laboratory and standard radiological examinations are the gold standard for diagnosing infection. The basis of optimal surgical treatment is precise debridement with the removal of all devitalized materials and foreign bodies containing mature biofilm. The standard procedure for acute infection is debridement, irrigation, change of movable parts and retention of the prosthesis. In chronic infections, patients with intact or mildly damaged soft tissue and microorganisms that are easily treated, complete replacement of the prosthesis in one stage is the treatment of choice. This procedure is associated with less morbidity and better functional outcome with no significant difference in cure rate compared with multistage revisions. The current concept of antimicrobial treatment includes 12 weeks of therapy. To achieve the best possible outcome, the addition of antibiotics that act on the biofilm is necessary. In order to prevent the emergence of antimicrobial resistance, these antibiotics should be used as a targeted therapy and added only after reinsertion of the prosthesis. The treatment of infection of a prosthetic joint is best performed by a multidisciplinary team consisting of an orthopedist, a clinical microbiologist, an infectious disease specialist, a physiotherapist and a nurse. These patients often remain bedridden for long periods of time, so physical therapy with joint exercises and muscle training is recommended. Dietary counseling can help prevent muscle wasting, and the nurse should ensure that the patient has prophylaxis against deep vein thrombosis and pressure ulcers. After discharge, most patients need months of active physical therapy to regain joint mobility and muscle strength.