Prostate cancer is the most commonly diagnosed malignant tumor in men in more than half of the world's countries, including the Republic of Croatia. It is most often detected in men older than 70 years. The most important risk factors for the onset of the disease are the patient's age, family history and lifestyle. The clinical picture of prostate cancer is non-specific and coincides with the symptoms of other conditions such as benign prostatic hyperplasia and prostatitis. Physical examination is limited and not specific or sensitive enough to make a diagnosis. At the end of the last century, the determination of prostate specific antigen (PSA) was introduced into clinical practice, which still plays a significant role in the screening of patients with suspected disease. Preoperative localization of prostate cancer is of vital importance in order to determine the therapeutic approach. Today, radiological methods and prostate biopsy are used for this purpose. At the moment, multiparametric magnetic resonance (mpMR) has the highest sensitivity and specificity of all radiological methods in the detection of prostate cancer, while new ultrasound technologies are actively sought to overcome it's disadvantages of cost and accessibility. Prostate biopsies still remain the gold standard for definitive diagnosis of prostate cancer. The ultimate goals of cancer therapy are to ensure control or complete cure of the disease, weighing the benefit of therapy against the risk of disease progression. The idea of focal therapy came from defining the index lesion, since radical surgical resections in most cases leave behind major consequences. The most important goal of focal therapy is to reduce the overall mortality rate associated with prostate cancer, and to reduce the morbidity caused either by the disease itself or that associated with treatment, as well as improving the overall quality of life of affected patients. Types of focal therapy used in clinical practice are: cryotherapy, high intensity focused ultrasound (HIFU), photodynamic therapy (PDT), focal laser ablation (FLA) and irreversible electroporation (IRE). Each of the mentioned techniques has its advantages and disadvantages, while special emphasis is placed on the need to conduct multicenter researches, the results of which would be used by experts for the purpose of writing guidelines for the proper selection of patients and therapeutic methods in order to improve oncological and functional outcomes.